DegronMD

Uniprot ID: Q9ULK2

Source protein: Ataxin-7-like protein 1

Source gene: ATXN7L1

Class: DEG_COP1_1

Location: 31:39

E3 ligase: COP1

DEGRON score: 0.8087

ASA_SCORE: 65.8444

COIL: 0.7303

CONS_SCORE: 0.2922

DSS_SCORE: 0.5002

HELIX: 0.2247

FCONS_SCORE: 0.8681

RIG_SCORE: 0.7625

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K35E	TCGA-34-5239	LUSC	TCGA	TLDRKVPSP	DEG_COP1_1	0.591
p.K35E	DO27660	LUSC	ICGC	TLDRKVPSP	DEG_COP1_1	0.591
p.K22R	TCGA-AP-A1DK	UCEC	TCGA	TLDRKVPSP	DEG_COP1_1	0.1944
p.K22R	DO42033	UCEC	ICGC	TLDRKVPSP	DEG_COP1_1	0.1944
p.Q24H	TCGA-AX-A0J0	UCEC	TCGA	TLDRKVPSP	DEG_COP1_1	0.1389
p.Q24H	DO41133	UCEC	ICGC	TLDRKVPSP	DEG_COP1_1	0.1389
p.R34S	TCGA-BR-A4QL	STAD	TCGA	TLDRKVPSP	DEG_COP1_1	0.6316
p.R34S	DO38723	STAD	ICGC	TLDRKVPSP	DEG_COP1_1	0.6316
p.P46L	TCGA-D3-A5GU	SKCM	TCGA	TLDRKVPSP	DEG_COP1_1	0.1389
p.P46L	DO47584	SKCM	ICGC	TLDRKVPSP	DEG_COP1_1	0.1389
p.L43V	TCGA-XF-A8HD	BLCA	TCGA	TLDRKVPSP	DEG_COP1_1	0.2222
p.L43V	DO49795	BLCA	ICGC	TLDRKVPSP	DEG_COP1_1	0.2222
p.K22N	DO233777	GACA	ICGC	TLDRKVPSP	DEG_COP1_1	0.1944
p.P46T	DO229034	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	0.1389
p.A41E	DO229034	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	0.2778
p.P39T	DO229036	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	0.7031
p.L32M	DO229008	LICA	ICGC	TLDRKVPSP	DEG_COP1_1	0.5999
p.S48P	DO48701	LIRI	ICGC	TLDRKVPSP	DEG_COP1_1	0.0833
p.V36M	DO46556	OV	ICGC	TLDRKVPSP	DEG_COP1_1	0.7208
p.D33H	SIDM00845	Burkitt's Lymphoma	GDSC	TLDRKVPSP	DEG_COP1_1	0.7688
p.D33H	SIDM00461	Acute Myeloid Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	0.7688
p.D33H	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	0.7688
p.D33H	SIDM01519	Head and Neck Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	0.7688
p.D33H	ACH-000786	Lymphoma	CCLE	TLDRKVPSP	DEG_COP1_1	0.7688
p.D33H	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	TLDRKVPSP	DEG_COP1_1	0.7688
p.R27T	SIDM00845	Burkitt's Lymphoma	GDSC	TLDRKVPSP	DEG_COP1_1	0.2222
p.R27T	SIDM00461	Acute Myeloid Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	0.2222
p.R27T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	TLDRKVPSP	DEG_COP1_1	0.2222
p.R27T	SIDM01519	Head and Neck Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	0.2222
p.R27T	ACH-000786	Lymphoma	CCLE	TLDRKVPSP	DEG_COP1_1	0.2222
p.R27T	ACH-000992	Head and Neck Cancer	CCLE	TLDRKVPSP	DEG_COP1_1	0.2222
p.R27T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	TLDRKVPSP	DEG_COP1_1	0.2222
p.F42L	SIDM01118	Small Cell Lung Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	0.25
p.F42L	ACH-002175	Lung Cancer	CCLE	TLDRKVPSP	DEG_COP1_1	0.25
p.F42L	NCI-H740	lung	COSMIC	TLDRKVPSP	DEG_COP1_1	0.25
p.P39A	SIDM00954	Breast Carcinoma	GDSC	TLDRKVPSP	DEG_COP1_1	0.6392
p.P39A	ACH-001820	Breast Cancer	CCLE	TLDRKVPSP	DEG_COP1_1	0.6392
p.P39A	COLO-824	breast	COSMIC	TLDRKVPSP	DEG_COP1_1	0.6392
p.Y40C	23132-87	stomach	COSMIC	TLDRKVPSP	DEG_COP1_1	0.3056
p.H43R	KYSE-70	oesophagus	COSMIC	TLDRKVPSP	DEG_COP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TLDRKVPSP

Degron related mutations and impact score

Drug responses associated with ATXN7L1 mutations

All proteins holding degron of TLDRKVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULK2	Ataxin-7-like protein 1	DEG_COP1_1	31:39	TLDRKVPSP	COP1	0.8087	More...