DegronMD

Uniprot ID: Q9ULK2

Source protein: Ataxin-7-like protein 1

Source gene: ATXN7L1

Class: DEG_APCC_DBOX_1

Location: 139:147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9521

ASA_SCORE: 101.3667

COIL: 0.7403

CONS_SCORE: 0.3026

DSS_SCORE: 0.5864

HELIX: 0.2424

FCONS_SCORE: 0.7586

RIG_SCORE: 0.7073

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G134R	DO10068	COAD	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.6389
p.H154Y	DO227745	COCA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.1389
p.D143N	DO233152	GACA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.6932
p.E142V	DO228278	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.7693
p.Q139K	DO228974	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.6944
p.H144N	DO229019	LICA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.7423
p.L153V	DO230937	LUSC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.1667
p.R139S	DO231022	LUSC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.7427
p.P130L	DO220877	MELA	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.0833
p.P157S	DO36556	READ	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.0556
p.F146L	DO43154	UCEC	ICGC	PRTSLVQVK	DEG_APCC_DBOX_1	0.6981
p.N138K	ACH-001551	Skin Cancer	CCLE	PRTSLVQVK	DEG_APCC_DBOX_1	0.3056
p.I139V	EFO-27	ovary	COSMIC	PRTSLVQVK	DEG_APCC_DBOX_1	0.7076

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULK2	Ataxin-7-like protein 1	DEG_APCC_DBOX_1	139:147	PRTSLVQVK	APC,CDC20,FZR1	0.9521	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons