DegronMD

Uniprot ID: Q9ULK2

Source protein: Ataxin-7-like protein 1

Source gene: ATXN7L1

Class: DEG_SPOP_SBC_1

Location: 647:651

E3 ligase: SPOP

DEGRON score: 0.9761

ASA_SCORE: 105.3

COIL: 0.961

CONS_SCORE: 0.3525

DSS_SCORE: 0.7151

HELIX: 0.0252

FCONS_SCORE: 1.042

RIG_SCORE: 0.4943

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S650L	TCGA-EY-A1G8	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.8778
p.S650L	DO43578	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.8778
p.S650L	SIDM00217	Colorectal Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.8778
p.D637Y	DO228896	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.0556
p.P647S	DO35442	PACA	ICGC	PQSST	DEG_SPOP_SBC_1	0.6752
p.S641I	DO51180	PAEN	ICGC	PQSST	DEG_SPOP_SBC_1	0.6111
p.D637N	SIDM00210	Ovarian Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.0556
p.D637N	A2780	ovary	COSMIC	PQSST	DEG_SPOP_SBC_1	0.0556
p.S661F	ACH-000882	Skin Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.0556
p.S649Y	ACH-000946	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.8231
p.S661Y	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	0.0556
p.S659L	SW684	soft_tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	0.1111
p.K655R	LS-180	large_intestine	COSMIC	PQSST	DEG_SPOP_SBC_1	0.6667
p.S661P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons