DegronMD

Uniprot ID: O15062

Source protein: Zinc finger and BTB domain-containing protein 5

Source gene: ZBTB5

Class: DEG_SPOP_SBC_1

Location: 382:386

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 79

COIL: 0.8914

CONS_SCORE: 0.8093

DSS_SCORE: 0.562

HELIX: 0.0752

FCONS_SCORE: 1.0043

RIG_SCORE: 0.6125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R377W	TCGA-B5-A11N	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.1944
p.R377W	DO41458	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.1944
p.R377L	TCGA-FS-A1ZG	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.1944
p.R377L	DO37523	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.1944
p.R377Q	DO221885	ALL	ICGC	PQSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons