DegronMD

Uniprot ID: Q9UQR0

Source protein: Sex comb on midleg-like protein 2

Source gene: SCML2

Class: DEG_SPOP_SBC_1

Location: 21:25

E3 ligase: SPOP

DEGRON score: 0.9781

ASA_SCORE: 83.64

COIL: 0.9354

CONS_SCORE: 0.6691

DSS_SCORE: 0.6862

HELIX: 0.0388

FCONS_SCORE: 0.9803

RIG_SCORE: 0.6153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D31Y	TCGA-55-8508	LUAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.1667
p.D31Y	DO45341	LUAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.1667
p.V28I	TCGA-AN-A0AK	BRCA	TCGA	PQSST	DEG_SPOP_SBC_1	0.25
p.V28I	DO1608	BRCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.25
p.D31H	TCGA-B0-5099	KIRC	TCGA	PQSST	DEG_SPOP_SBC_1	0.1667
p.D31H	DO16317	KIRC	ICGC	PQSST	DEG_SPOP_SBC_1	0.1667
p.Q22K	TCGA-CV-7091	HNSC	TCGA	PQSST	DEG_SPOP_SBC_1	0.5833
p.Q22K	DO14212	HNSC	ICGC	PQSST	DEG_SPOP_SBC_1	0.5833
p.Q22K	DO229045	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.5833
p.D32N	TCGA-EE-A3JI	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.1389
p.D32N	DO47268	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.1389
p.S26Y	TCGA-EO-A3B0	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.3056
p.S26Y	DO219773	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.3056
p.S26F	TCGA-FR-A726	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.3056
p.S26F	DO48665	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.3056
p.F33L	DO229037	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.1111
p.Q17K	SIDM00619	Thyroid Gland Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.2222
p.Q17K	ACH-002397	Thyroid Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.2222
p.Q17K	KMH-2	thyroid	COSMIC	PQSST	DEG_SPOP_SBC_1	0.2222
p.V12A	SIDM00217	Colorectal Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.0833
p.V12A	ACH-000999	Colon/Colorectal Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.0833
p.V12A	SNU-1040	large_intestine	COSMIC	PQSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons