DegronMD - Q01844(EWSR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S184N	TCGA-55-7910	LUAD	TCGA	PPSY	ITCH	187:190	Mutation rewiring degron network	0.25
p.P142S	TCGA-AP-A0LD	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0833
p.P145L	TCGA-AP-A1DK	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.P145L	TCGA-IB-7651	PAAD	TCGA	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.P182H	TCGA-DA-A1I1	SKCM	TCGA	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.P197H	TCGA-DJ-A2QB	THCA	TCGA	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1389
p.T154A	TCGA-DM-A0X9	COAD	TCGA	PQSST	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7139
p.Q180K	TCGA-G7-6797	KIRP	TCGA	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1389
p.Q180K	DO20917	KIRP	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1389
p.G148A	TCGA-LN-A49M	ESCA	TCGA	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.25
p.P182R	TCGA-RP-A695	SKCM	TCGA	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.P182R	DO51270	SKCM	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.S159F	DO225046	BRCA	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2222
p.T148A	DO8618	COAD	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.25
p.A186G	DO233153	GACA	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.3056
p.P197R	DO233262	GACA	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1389
p.D147Y	DO229026	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.2222
p.Y195N	DO50883	LICA	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.G163S	DO231683	LINC	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1111
p.G164R	DO23525	LIRI	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0833
p.S178N	DO23669	LUAD	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.0833
p.Q150K	DO228489	PRAD	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.3056
p.S195F	DO219879	SKCA	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1944
p.P161H	DO37438	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1667
p.N165K	DO229227	THCA	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0556
p.P191H	DO39421	THCA	ICGC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.3056
p.Q160H	DO43755	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.1944
p.T198S	ACH-000992	Head and Neck Cancer	CCLE	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1111
p.T198S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.1111
p.Y152C	HCT-15	large intestine	COSMIC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation altering degron motif	0.7087
p.T142S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	151:155	Mutation rewiring degron network	0.0833
p.T199S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPSY	ITCH	187:190	Mutation rewiring degron network	0.0833

Kaplan plot for EWSR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EWSR1

UniProt ID: Q01844

Entrez ID: 2130

Protein name: RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EWSR1 in