DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PQSST
Uniprot ID:
Q01844
Source protein:
RNA-binding protein EWS
Source gene:
EWSR1
Class:
DEG_SPOP_SBC_1
Location:
151:155
E3 ligase:
SPOP
DEGRON score:
0.8757
ASA_SCORE:
71.02
COIL:
0.8894
CONS_SCORE:
0.2417
DSS_SCORE:
0.7911
HELIX:
0.0394
FCONS_SCORE:
0.9304
RIG_SCORE:
0.5605
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P142S
TCGA-AP-A0LD
UCEC
TCGA
PQSST
DEG_SPOP_SBC_1
0.0833
p.P145L
TCGA-AP-A1DK
UCEC
TCGA
PQSST
DEG_SPOP_SBC_1
0.1667
p.P145L
TCGA-IB-7651
PAAD
TCGA
PQSST
DEG_SPOP_SBC_1
0.1667
p.T154A
TCGA-DM-A0X9
COAD
TCGA
PQSST
DEG_SPOP_SBC_1
0.7139
p.G148A
TCGA-LN-A49M
ESCA
TCGA
PQSST
DEG_SPOP_SBC_1
0.25
p.S159F
DO225046
BRCA
ICGC
PQSST
DEG_SPOP_SBC_1
0.2222
p.T148A
DO8618
COAD
ICGC
PQSST
DEG_SPOP_SBC_1
0.25
p.D147Y
DO229026
LICA
ICGC
PQSST
DEG_SPOP_SBC_1
0.2222
p.G163S
DO231683
LINC
ICGC
PQSST
DEG_SPOP_SBC_1
0.1111
p.G164R
DO23525
LIRI
ICGC
PQSST
DEG_SPOP_SBC_1
0.0833
p.Q150K
DO228489
PRAD
ICGC
PQSST
DEG_SPOP_SBC_1
0.3056
p.P161H
DO37438
SKCM
ICGC
PQSST
DEG_SPOP_SBC_1
0.1667
p.N165K
DO229227
THCA
ICGC
PQSST
DEG_SPOP_SBC_1
0.0556
p.Q160H
DO43755
UCEC
ICGC
PQSST
DEG_SPOP_SBC_1
0.1944
p.Y152C
HCT-15
large_intestine
COSMIC
PQSST
DEG_SPOP_SBC_1
0.7087
p.T142S
Daudi
haematopoietic_and_lymphoid_tissue
COSMIC
PQSST
DEG_SPOP_SBC_1
0.0833
Drug responses associated with EWSR1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14964
Hepatocyte growth factor-regulated tyrosine kinase substrate
DEG_SPOP_SBC_1
689:693
PQSST
SPOP
0.9823
More...
O15062
Zinc finger and BTB domain-containing protein 5
DEG_SPOP_SBC_1
382:386
PQSST
SPOP
0.9983
More...
P08069
Insulin-like growth factor 1 receptor
DEG_SPOP_SBC_1
1362:1366
PQSST
SPOP
0.9661
More...
Q01844
RNA-binding protein EWS
DEG_SPOP_SBC_1
151:155
PQSST
SPOP
0.8757
More...
Q86XJ1
GAS2-like protein 3
DEG_SPOP_SBC_1
619:623
PQSST
SPOP
0.9841
More...
Q93052
Lipoma-preferred partner
DEG_SPOP_SBC_1
142:146
PQSST
SPOP
0.9235
More...
Q9UQR0
Sex comb on midleg-like protein 2
DEG_SPOP_SBC_1
21:25
PQSST
SPOP
0.9781
More...
P63132
Endogenous retrovirus group K member 113 Pol protein
DEG_SPOP_SBC_1
875:879
PQSST
SPOP
0.8663
More...
P63136
Endogenous retrovirus group K member 25 Pol protein
DEG_SPOP_SBC_1
873:877
PQSST
SPOP
0.5968
More...
Q9ULK2
Ataxin-7-like protein 1
DEG_SPOP_SBC_1
647:651
PQSST
SPOP
0.9761
More...
Q2KHR3
Glutamine and serine-rich protein 1
DEG_SPOP_SBC_1
129:133
PQSST
SPOP
0.9614
More...