DegronMD

Uniprot ID: Q01844

Source protein: RNA-binding protein EWS

Source gene: EWSR1

Class: DEG_SPOP_SBC_1

Location: 151:155

E3 ligase: SPOP

DEGRON score: 0.8757

ASA_SCORE: 71.02

COIL: 0.8894

CONS_SCORE: 0.2417

DSS_SCORE: 0.7911

HELIX: 0.0394

FCONS_SCORE: 0.9304

RIG_SCORE: 0.5605

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T154A	TCGA-DM-A0X9	COAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.7139
p.Y152C	HCT-15	large_intestine	COSMIC	PQSST	DEG_SPOP_SBC_1	0.7087
p.Q150K	DO228489	PRAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.3056
p.G148A	TCGA-LN-A49M	ESCA	TCGA	PQSST	DEG_SPOP_SBC_1	0.25
p.T148A	DO8618	COAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.25
p.S159F	DO225046	BRCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.2222
p.D147Y	DO229026	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.2222
p.Q160H	DO43755	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.1944
p.P145L	TCGA-AP-A1DK	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.1667
p.P145L	TCGA-IB-7651	PAAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.1667
p.P161H	DO37438	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.1667
p.G163S	DO231683	LINC	ICGC	PQSST	DEG_SPOP_SBC_1	0.1111
p.P142S	TCGA-AP-A0LD	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.0833
p.G164R	DO23525	LIRI	ICGC	PQSST	DEG_SPOP_SBC_1	0.0833
p.T142S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	0.0833
p.N165K	DO229227	THCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...

Showing 1 to 11 of 11 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons