DegronMD - Q86XJ1(GAS2L3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G601A	TCGA-17-Z022	LUAD	TCGA	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation rewiring degron network	0.1111
p.Q450H	TCGA-AX-A0J0	UCEC	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.3056
p.Q450H	DO41133	UCEC	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.3056
p.V616M	TCGA-B5-A3FC	UCEC	TCGA	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation altering degron motif	0.6097
p.V616M	DO41871	UCEC	ICGC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation altering degron motif	0.6097
p.P448A	TCGA-BR-8296	STAD	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.7503
p.P448A	DO38539	STAD	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.7503
p.A449D	TCGA-CK-6746	COAD	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.6682
p.A449D	DO7938	COAD	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.6682
p.P629L	TCGA-CV-7097	HNSC	TCGA	PQSST	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1667
p.P629L	DO14886	HNSC	ICGC	PQSST	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1667
p.S438F	TCGA-E8-A418	THCA	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation blocking phosphorylation signal	0.6944
p.S438F	DO39481	THCA	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation blocking phosphorylation signal	0.6944
p.N440D	TCGA-F5-6814	READ	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.3056
p.N440D	DO36556	READ	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.3056
p.R433I	TCGA-FI-A2D5	UCEC	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.1111
p.R433I	DO41331	UCEC	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.1111
p.A453V	TCGA-WK-A8XY	SARC	TCGA	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.2222
p.A453V	DO220301	SARC	ICGC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.2222
p.P608R	DO225012	BRCA	ICGC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation rewiring degron network	0.3056
p.K599Q	DO227558	PACA	ICGC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation substituting flanking lysine	0.1667
p.A628T	SIDM02026	Colorectal Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1944
p.L605M	SIDM00955	Melanoma	GDSC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation rewiring degron network	0.2222
p.L605M	COLO-783	skin	COSMIC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation rewiring degron network	0.2222
p.A628S	SIDM00120	Prostate Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1944
p.A628S	DU-145	prostate	COSMIC	PQSST	DEG_SPOP_SBC_1	619:623	Mutation rewiring degron network	0.1944
p.L605S	SIDM00282	Colorectal Carcinoma	GDSC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation rewiring degron network	0.2222
p.L605S	CW-2	large intestine	COSMIC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation rewiring degron network	0.2222
p.P612L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation altering degron motif	0.6471
p.P612L	NCI-H23	lung	COSMIC	GRTPLSIVS	DEG_APCC_DBOX_1	609:617	Mutation altering degron motif	0.6471
p.T441N	SIDM01140	Ovarian Carcinoma	GDSC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.7055
p.T441N	PA-1	ovary	COSMIC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.7055
p.V445F	ACH-000681	Lung Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.7068
p.V445F	A549	lung	COSMIC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation altering degron motif	0.7068
p.Q432L	ACH-000791	Lung Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.0833
p.A439V	ACH-000984	Endometrial/Uterine Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.2778
p.A439S	ACH-002275	Leukemia	CCLE	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.2778
p.A439S	MN-60	haematopoietic and lymphoid tissue	COSMIC	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.2778
p.P440S	ACH-002388	Skin Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	441:449	Mutation rewiring degron network	0.3056

Kaplan plot for GAS2L3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAS2L3

UniProt ID: Q86XJ1

Entrez ID: 283431

Protein name: GAS2-like protein 3 (Growth arrest-specific protein 2-like 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAS2L3 in