DegronMD

Uniprot ID: Q86XJ1

Source protein: GAS2-like protein 3

Source gene: GAS2L3

Class: DEG_SIAH_1

Location: 441:449

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9952

ASA_SCORE: 103.1111

COIL: 0.9439

CONS_SCORE: 0.2795

DSS_SCORE: 0.5622

HELIX: 0.0258

FCONS_SCORE: 0.8769

RIG_SCORE: 0.6968

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q450H	TCGA-AX-A0J0	UCEC	TCGA	TPKAKVIPA	DEG_SIAH_1	0.3056
p.Q450H	DO41133	UCEC	ICGC	TPKAKVIPA	DEG_SIAH_1	0.3056
p.P448A	TCGA-BR-8296	STAD	TCGA	TPKAKVIPA	DEG_SIAH_1	0.7503
p.P448A	DO38539	STAD	ICGC	TPKAKVIPA	DEG_SIAH_1	0.7503
p.A449D	TCGA-CK-6746	COAD	TCGA	TPKAKVIPA	DEG_SIAH_1	0.6682
p.A449D	DO7938	COAD	ICGC	TPKAKVIPA	DEG_SIAH_1	0.6682
p.S438F	TCGA-E8-A418	THCA	TCGA	TPKAKVIPA	DEG_SIAH_1	0.6944
p.S438F	DO39481	THCA	ICGC	TPKAKVIPA	DEG_SIAH_1	0.6944
p.N440D	TCGA-F5-6814	READ	TCGA	TPKAKVIPA	DEG_SIAH_1	0.3056
p.N440D	DO36556	READ	ICGC	TPKAKVIPA	DEG_SIAH_1	0.3056
p.R433I	TCGA-FI-A2D5	UCEC	TCGA	TPKAKVIPA	DEG_SIAH_1	0.1111
p.R433I	DO41331	UCEC	ICGC	TPKAKVIPA	DEG_SIAH_1	0.1111
p.A453V	TCGA-WK-A8XY	SARC	TCGA	TPKAKVIPA	DEG_SIAH_1	0.2222
p.A453V	DO220301	SARC	ICGC	TPKAKVIPA	DEG_SIAH_1	0.2222
p.T441N	SIDM01140	Ovarian Carcinoma	GDSC	TPKAKVIPA	DEG_SIAH_1	0.7055
p.T441N	PA-1	ovary	COSMIC	TPKAKVIPA	DEG_SIAH_1	0.7055
p.V445F	ACH-000681	Lung Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	0.7068
p.V445F	A549	lung	COSMIC	TPKAKVIPA	DEG_SIAH_1	0.7068
p.Q432L	ACH-000791	Lung Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	0.0833
p.A439V	ACH-000984	Endometrial/Uterine Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	0.2778
p.A439S	ACH-002275	Leukemia	CCLE	TPKAKVIPA	DEG_SIAH_1	0.2778
p.A439S	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	TPKAKVIPA	DEG_SIAH_1	0.2778
p.P440S	ACH-002388	Skin Cancer	CCLE	TPKAKVIPA	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XJ1	GAS2-like protein 3	DEG_SIAH_1	441:449	TPKAKVIPA	SIAH1,SIAH2,SIAH3	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons