DegronMD

Uniprot ID: Q86XJ1

Source protein: GAS2-like protein 3

Source gene: GAS2L3

Class: DEG_APCC_DBOX_1

Location: 609:617

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9716

ASA_SCORE: 84.9556

COIL: 0.8833

CONS_SCORE: 0.3705

DSS_SCORE: 0.6739

HELIX: 0.0451

FCONS_SCORE: 1.1097

RIG_SCORE: 0.6579

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G601A	TCGA-17-Z022	LUAD	TCGA	GRTPLSIVS	DEG_APCC_DBOX_1	0.1111
p.V616M	TCGA-B5-A3FC	UCEC	TCGA	GRTPLSIVS	DEG_APCC_DBOX_1	0.6097
p.V616M	DO41871	UCEC	ICGC	GRTPLSIVS	DEG_APCC_DBOX_1	0.6097
p.P608R	DO225012	BRCA	ICGC	GRTPLSIVS	DEG_APCC_DBOX_1	0.3056
p.K599Q	DO227558	PACA	ICGC	GRTPLSIVS	DEG_APCC_DBOX_1	0.1667
p.L605M	SIDM00955	Melanoma	GDSC	GRTPLSIVS	DEG_APCC_DBOX_1	0.2222
p.L605M	COLO-783	skin	COSMIC	GRTPLSIVS	DEG_APCC_DBOX_1	0.2222
p.L605S	SIDM00282	Colorectal Carcinoma	GDSC	GRTPLSIVS	DEG_APCC_DBOX_1	0.2222
p.L605S	CW-2	large_intestine	COSMIC	GRTPLSIVS	DEG_APCC_DBOX_1	0.2222
p.P612L	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	GRTPLSIVS	DEG_APCC_DBOX_1	0.6471
p.P612L	NCI-H23	lung	COSMIC	GRTPLSIVS	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86XJ1	GAS2-like protein 3	DEG_APCC_DBOX_1	609:617	GRTPLSIVS	APC,CDC20,FZR1	0.9716	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons