DegronMD

Uniprot ID: O14964

Source protein: Hepatocyte growth factor-regulated tyrosine kinase substrate

Source gene: HGS

Class: DEG_SPOP_SBC_1

Location: 689:693

E3 ligase: SPOP

DEGRON score: 0.9823

ASA_SCORE: 80.6

COIL: 0.9236

CONS_SCORE: 0.467

DSS_SCORE: 0.5662

HELIX: 0.0378

FCONS_SCORE: 0.9729

RIG_SCORE: 0.6071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S691Y	TCGA-EE-A29Q	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.712
p.S691Y	DO37866	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.712
p.P689T	TCGA-EE-A2MG	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.7031
p.P689T	DO37421	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.7031
p.S701L	TCGA-FD-A3SO	BLCA	TCGA	PQSST	DEG_SPOP_SBC_1	0.1111
p.S701L	TCGA-FD-A43P	BLCA	TCGA	PQSST	DEG_SPOP_SBC_1	0.1111
p.S701L	DO44049	BLCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.1111
p.S701L	DO569	BLCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.1111
p.S703F	TCGA-IB-7651	PAAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.0556
p.S703F	DO46657	PAAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.0556
p.M694V	TCGA-ZG-A9LS	PRAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.3056
p.M694V	DO219434	PRAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.3056
p.M694V	SIDM00472	Ovarian Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.3056
p.M694V	ACH-001630	Ovarian Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.3056
p.M694V	PEO1	ovary	COSMIC	PQSST	DEG_SPOP_SBC_1	0.3056
p.M697T	DO233259	GACA	ICGC	PQSST	DEG_SPOP_SBC_1	0.2222
p.P683T	DO222413	MELA	ICGC	PQSST	DEG_SPOP_SBC_1	0.1667
p.P689L	DO230449	UTCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.7582
p.S703Y	SIDM00614	Hepatocellular Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.0556
p.S703Y	ACH-000848	Liver Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.0556
p.S703Y	JHH-7	liver	COSMIC	PQSST	DEG_SPOP_SBC_1	0.0556
p.P683L	SIDM01608	Endometrial Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.1667
p.P683L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons