DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PQSST
Uniprot ID:
P63136
Source protein:
Endogenous retrovirus group K member 25 Pol protein
Source gene:
ERVK-25
Class:
DEG_SPOP_SBC_1
Location:
873:877
E3 ligase:
SPOP
DEGRON score:
0.5968
ASA_SCORE:
96.18
COIL:
0.929
CONS_SCORE:
0.2204
DSS_SCORE:
0.7608
HELIX:
0.0566
FCONS_SCORE:
0.9581
RIG_SCORE:
0.6186
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with ERVK-25 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PQSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O14964
Hepatocyte growth factor-regulated tyrosine kinase substrate
DEG_SPOP_SBC_1
689:693
PQSST
SPOP
0.9823
More...
O15062
Zinc finger and BTB domain-containing protein 5
DEG_SPOP_SBC_1
382:386
PQSST
SPOP
0.9983
More...
P08069
Insulin-like growth factor 1 receptor
DEG_SPOP_SBC_1
1362:1366
PQSST
SPOP
0.9661
More...
Q01844
RNA-binding protein EWS
DEG_SPOP_SBC_1
151:155
PQSST
SPOP
0.8757
More...
Q86XJ1
GAS2-like protein 3
DEG_SPOP_SBC_1
619:623
PQSST
SPOP
0.9841
More...
Q93052
Lipoma-preferred partner
DEG_SPOP_SBC_1
142:146
PQSST
SPOP
0.9235
More...
Q9UQR0
Sex comb on midleg-like protein 2
DEG_SPOP_SBC_1
21:25
PQSST
SPOP
0.9781
More...
P63132
Endogenous retrovirus group K member 113 Pol protein
DEG_SPOP_SBC_1
875:879
PQSST
SPOP
0.8663
More...
P63136
Endogenous retrovirus group K member 25 Pol protein
DEG_SPOP_SBC_1
873:877
PQSST
SPOP
0.5968
More...
Q9ULK2
Ataxin-7-like protein 1
DEG_SPOP_SBC_1
647:651
PQSST
SPOP
0.9761
More...
Q2KHR3
Glutamine and serine-rich protein 1
DEG_SPOP_SBC_1
129:133
PQSST
SPOP
0.9614
More...