DegronMD

Uniprot ID: P08069

Source protein: Insulin-like growth factor 1 receptor

Source gene: IGF1R

Class: DEG_SPOP_SBC_1

Location: 1362:1366

E3 ligase: SPOP

DEGRON score: 0.9661

ASA_SCORE: 79.9

COIL: 0.7708

CONS_SCORE: 0.4516

DSS_SCORE: 0.8681

HELIX: 0.1162

FCONS_SCORE: 0.9945

RIG_SCORE: 0.6607

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1365L	TCGA-A5-A0G2	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.7667
p.S1365L	SIDM00061	Ovarian Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.7667
p.R1357L	TCGA-EE-A3AA	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.1944
p.T1366A	TCGA-IB-7651	PAAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.825
p.K1353N	DO224739	COCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.0833
p.E1355V	DO50762	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.1389
p.S1364L	DO220873	MELA	ICGC	PQSST	DEG_SPOP_SBC_1	0.7667
p.S1364L	DO41235	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.7667
p.T1365A	DO46657	PAAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.7139
p.R1356L	DO37571	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.1667
p.R1353H	SIDM01043	Other Sarcomas	GDSC	PQSST	DEG_SPOP_SBC_1	0.0833

Drug responses associated with IGF1R mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000065	Leukemia	p.L17V (No)	CCLE	AEW541	1.2382
ACH-000879	Endometrial/Uterine Cancer	p.D38N (No)	CCLE	AEW541	7.5018
ACH-000978	Endometrial/Uterine Cancer	p.L133P (No)	CCLE	AEW541	8
ACH-000599	Pancreatic Cancer	p.D162N (No)	CCLE	AEW541	3.1226
ACH-000014	Metastasis	p.A241T (No)	CCLE	AEW541	3.6686
ACH-000974	Endometrial/Uterine Cancer	p.R252C (No)	CCLE	AEW541	8
ACH-000960	Leukemia	p.V259I (No)	CCLE	AEW541	4.6579
ACH-000973	Bladder Cancer	p.R275C (No)	CCLE	AEW541	1.7362
ACH-000721	Breast Cancer	p.I298F (No)	CCLE	AEW541	3.8056
ACH-000366	Neuroblastoma	p.L360F (No)	CCLE	AEW541	1.3
ACH-000841	Lung Cancer	p.G410V (No)	CCLE	AEW541	7.7227
ACH-000985	Colon/Colorectal Cancer	p.R461H (No)	CCLE	AEW541	2.9961
ACH-000245	Lymphoma	p.V554M (No)	CCLE	AEW541	8
ACH-000994	Endometrial/Uterine Cancer	p.I594V (No)	CCLE	AEW541	8
ACH-000978	Endometrial/Uterine Cancer	p.K630R (No)	CCLE	AEW541	8
ACH-000960	Leukemia	p.T758M (No)	CCLE	AEW541	4.6579
ACH-000997	Colon/Colorectal Cancer	p.N792D (No)	CCLE	AEW541	4.6306
ACH-000958	Colon/Colorectal Cancer	p.A828T (No)	CCLE	AEW541	0.6875
ACH-000994	Endometrial/Uterine Cancer	p.R904Q (No)	CCLE	AEW541	8
ACH-000979	Prostate Cancer	p.S909fs (No)	CCLE	AEW541	6.6821
ACH-000994	Endometrial/Uterine Cancer	p.A938T (No)	CCLE	AEW541	8
ACH-000966	Ovarian Cancer	p.V942I (No)	CCLE	AEW541	8
ACH-000987	Skin Cancer	p.P989S (No)	CCLE	AEW541	8
ACH-000587	Lung Cancer	p.E1037K (No)	CCLE	AEW541	8
ACH-000728	Leukemia	p.R1041C (No)	CCLE	AEW541	6.6841
ACH-000997	Colon/Colorectal Cancer	p.S1093F (No)	CCLE	AEW541	4.6306
ACH-000183	Myeloma	p.D1146N (No)	CCLE	AEW541	0.5981
ACH-000997	Colon/Colorectal Cancer	p.R1246C (No)	CCLE	AEW541	4.6306
ACH-000918	Leukemia	p.I1266T (No)	CCLE	AEW541	5.8091
ACH-000789	Lung Cancer	p.E1289* (No)	CCLE	AEW541	2.8553
ACH-000973	Bladder Cancer	p.V1303I (No)	CCLE	AEW541	1.7362
ACH-000931	Skin Cancer	p.D1317N (No)	CCLE	AEW541	5.2392
ACH-001024	Skin Cancer	p.D1317N (No)	CCLE	AEW541	7.182
ACH-001041	Lung Cancer	p.D1317N (No)	CCLE	AEW541	2.2132
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-536924	18.6094
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-754807	0.9746
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	Linsitinib	11.1403
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	GSK1904529A	4.8207
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-536924	16.3469
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	BMS-536924	10.922
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	GSK1904529A	18.74
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	Linsitinib	28.659
SIDM00121	ALL\|lymphoblastic_leukemia	p.R107H (No)	GDSC	NVP-ADW742	9.5311
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	BMS-754807	3.4953
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	Linsitinib	9.7517
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	GSK1904529A	4.002
SIDM00924	UNCLASSIFIED\|lung_NSCLC_not_specified	p.G929E (No)	GDSC	BMS-536924	5.2177
SIDM00515	SKCM\|melanoma	p.E772K (No)	GDSC	BMS-536924	53.8366
SIDM00515	SKCM\|melanoma	p.E772K (No)	GDSC	BMS-754807	1.1705
SIDM00515	SKCM\|melanoma	p.E772K (No)	GDSC	BMS-536924	1.1315
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	BMS-754807	3.0165
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	Linsitinib	25.6441
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	GSK1904529A	7.6116
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	BMS-536924	4.6752
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	BMS-536924	11.19
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	GSK1904529A	45.847
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	Linsitinib	28.297
SIDM01228	SKCM\|melanoma	p.D1318N (No)	GDSC	NVP-ADW742	59.296
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	BMS-536924	7.806
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	BMS-536924	1.3789
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	GSK1904529A	84.878
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	Linsitinib	112.51
SIDM00151	OV\|ovary	p.V942I (No)	GDSC	NVP-ADW742	9.9393
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-536924	4.1048
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-754807	1.1106
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	Linsitinib	6.5289
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	GSK1904529A	5.9932
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-536924	6.0431
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	BMS-536924	18.543
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	GSK1904529A	53.026
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	Linsitinib	24.246
SIDM00145	ALL\|lymphoblastic_leukemia	p.S915L (No)	GDSC	NVP-ADW742	19.863
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	BMS-754807	0.5062
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	Linsitinib	1.3486
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	GSK1904529A	15.5697
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	BMS-536924	2.6085
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	BMS-536924	8.2357
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	GSK1904529A	240.31
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	Linsitinib	23.242
SIDM00455	PAAD\|pancreas	p.D162N (No)	GDSC	NVP-ADW742	20.087
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	BMS-754807	1.9536
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	Linsitinib	34.1591
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	GSK1904529A	17.1578
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	BMS-536924	5.9774
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	BMS-536924	27.995
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	GSK1904529A	216.87
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	Linsitinib	189.14
SIDM00334	UCEC\|endometrium	p.D38N (No)	GDSC	NVP-ADW742	145.35
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	BMS-536924	0.2337
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	BMS-754807	0.0751
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	Linsitinib	0.2584
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	GSK1904529A	8.7259
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	BMS-536924	0.7533
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	GSK1904529A	73.249
SIDM00461	LAML\|acute_myeloid_leukaemia	p.L17V (No)	GDSC	Linsitinib	7.1126
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	BMS-536924	99.0113
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	BMS-754807	23.2593
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	Linsitinib	51.561
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	GSK1904529A	11.8548
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	BMS-536924	50.8325
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	GSK1904529A	35.294
SIDM00293	SCLC\|lung_small_cell_carcinoma	p.G1322* (No)	GDSC	Linsitinib	56.676
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-536924	3.2462
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-754807	1.112
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	Linsitinib	4.9193
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	GSK1904529A	7.4024
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-536924	19.685
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	BMS-536924	4.6307
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	GSK1904529A	25.097
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	Linsitinib	10.052
SIDM01007	ALL\|lymphoblastic_leukemia	p.S343F (No)	GDSC	NVP-ADW742	4.2679
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-536924	2.2448
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-754807	0.9612
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	Linsitinib	29.7551
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	GSK1904529A	12.373
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-536924	11.5478
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	BMS-536924	20.545
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	GSK1904529A	154.54
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	Linsitinib	117.09
SIDM00801	SKCM\|melanoma	p.A241T (No)	GDSC	NVP-ADW742	6.8166
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-536924	0.3233
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-754807	0.4122
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	Linsitinib	1.1702
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	GSK1904529A	5.1935
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-536924	0.7089
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	BMS-536924	0.5274
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	GSK1904529A	21.319
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	Linsitinib	3.196
SIDM00312	MM\|myeloma	p.D1146N (No)	GDSC	NVP-ADW742	5.8584
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	BMS-754807	1.3615
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	Linsitinib	5.1518
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	GSK1904529A	5.2757
SIDM00690	HNSC\|head_and_neck	p.R794Q (No)	GDSC	BMS-536924	2.6847
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	BMS-754807	2.9163
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	Linsitinib	22.6958
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	GSK1904529A	16.0001
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	BMS-536924	9.3877
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	BMS-536924	13.638
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	GSK1904529A	180.02
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	Linsitinib	167.49
SIDM00377	UNCLASSIFIED\|uterus	p.P842S (No)	GDSC	NVP-ADW742	85.828
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	BMS-536924	6.0294
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	BMS-754807	3.1338
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	Linsitinib	9.4936
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	GSK1904529A	15.4829
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	BMS-536924	55.4927
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	GSK1904529A	5391.5
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V456fs*13 (No)	GDSC	Linsitinib	6292.2
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	BMS-754807	1.998
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	Linsitinib	19.889
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	GSK1904529A	6.1763
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	BMS-536924	13.6715
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	BMS-536924	3.7641
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	GSK1904529A	20.092
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	Linsitinib	54.855
SIDM01043	UNCLASSIFIED\|endometrium	p.R1353H (Yes)	GDSC	NVP-ADW742	8.798
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-536924	3.6721
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-754807	20.0778
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	Linsitinib	15.7269
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	GSK1904529A	7.9336
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-536924	4.5531
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	BMS-536924	4.9315
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	GSK1904529A	8.5
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	Linsitinib	13.647
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.G310S (No)	GDSC	NVP-ADW742	6.3464
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-536924	9.9614
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-754807	5.1511
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	Linsitinib	34.2619
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	GSK1904529A	13.7092
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-536924	10.224
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	BMS-536924	5.5863
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	GSK1904529A	15.334
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	Linsitinib	60.148
SIDM00965	SCLC\|lung_small_cell_carcinoma	p.T524S (No)	GDSC	NVP-ADW742	5.7721
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	BMS-754807	2.3791
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	Linsitinib	38.2735
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	GSK1904529A	6.4455
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	BMS-536924	29
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	BMS-536924	93.232
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	GSK1904529A	75.246
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	Linsitinib	97.889
SIDM01045	UCEC\|endometrium	p.L133P (No)	GDSC	NVP-ADW742	100.71
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	BMS-754807	2.3791
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	Linsitinib	38.2735
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	GSK1904529A	6.4455
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	BMS-536924	29
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	BMS-536924	93.232
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	GSK1904529A	75.246
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	Linsitinib	97.889
SIDM01045	UCEC\|endometrium	p.I298V (No)	GDSC	NVP-ADW742	100.71
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	BMS-754807	2.3791
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	Linsitinib	38.2735
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	GSK1904529A	6.4455
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	BMS-536924	29
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	BMS-536924	93.232
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	GSK1904529A	75.246
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	Linsitinib	97.889
SIDM01045	UCEC\|endometrium	p.K630R (No)	GDSC	NVP-ADW742	100.71
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-536924	1.8469
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-754807	3.8991
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	Linsitinib	4.9529
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	GSK1904529A	4.3618
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-536924	2.9752
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	BMS-536924	6.5718
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	GSK1904529A	27.544
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	Linsitinib	23.367
SIDM00946	ALL\|T_cell_leukemia	p.L17V (No)	GDSC	NVP-ADW742	6.4343
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-536924	1.8469
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-754807	3.8991
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	Linsitinib	4.9529
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	GSK1904529A	4.3618
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-536924	2.9752
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	BMS-536924	6.5718
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	GSK1904529A	27.544
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	Linsitinib	23.367
SIDM00946	ALL\|T_cell_leukemia	p.R739W (No)	GDSC	NVP-ADW742	6.4343
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.R275C (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.A395T (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.M826I (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.S1308L (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.S1308L (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.S1308L (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.S1308L (No)	GDSC	BMS-754807	6.9063
SIDM00217	COREAD\|large_intestine	p.S1311L (No)	GDSC	BMS-536924	78.5208
SIDM00217	COREAD\|large_intestine	p.S1311L (No)	GDSC	GSK1904529A	173.24
SIDM00217	COREAD\|large_intestine	p.S1311L (No)	GDSC	Linsitinib	100.91
SIDM00217	COREAD\|large_intestine	p.S1311L (No)	GDSC	BMS-754807	6.9063
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-536924	16.1072
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-754807	35.286
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	Linsitinib	35.106
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	GSK1904529A	14.1656
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-536924	13.5952
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	BMS-536924	10.783
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	GSK1904529A	105.88
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	Linsitinib	47.158
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.G1229S (No)	GDSC	NVP-ADW742	5.5686
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	BMS-536924	4.3897
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	GSK1904529A	13.992
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	Linsitinib	9.9234
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	NVP-ADW742	11.105
SIDM00216	COREAD\|large_intestine	p.T79A (No)	GDSC	BMS-754807	0.2294
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	BMS-536924	4.3897
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	GSK1904529A	13.992
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	Linsitinib	9.9234
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	NVP-ADW742	11.105
SIDM00216	COREAD\|large_intestine	p.R471C (No)	GDSC	BMS-754807	0.2294
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	BMS-536924	4.3897
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	GSK1904529A	13.992
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	Linsitinib	9.9234
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	NVP-ADW742	11.105
SIDM00216	COREAD\|large_intestine	p.R1337C (No)	GDSC	BMS-754807	0.2294
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	BMS-754807	7.0493
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	Linsitinib	27.5972
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	GSK1904529A	6.0036
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	BMS-536924	15.7819
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	BMS-536924	27.008
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	GSK1904529A	103.37
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	Linsitinib	48.994
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.N284Y (No)	GDSC	NVP-ADW742	118
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	BMS-754807	1.036
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	Linsitinib	15.1526
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	GSK1904529A	4.5646
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	BMS-536924	13.986
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	BMS-536924	2.6893
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	GSK1904529A	31.745
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	Linsitinib	41.802
SIDM00685	GBM\|glioma	p.V579I (No)	GDSC	NVP-ADW742	7.6499
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-536924	0.5436
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-754807	0.1578
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	Linsitinib	1.3628
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	GSK1904529A	2.9894
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-536924	7.0012
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-536924	1.6249
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	GSK1904529A	64.316
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	Linsitinib	31.353
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	NVP-ADW742	1.4156
SIDM00660	COREAD\|large_intestine	p.R461H (No)	GDSC	BMS-754807	5.2852
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-536924	24.3843
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-754807	11.544
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	Linsitinib	27.0772
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	GSK1904529A	3.4053
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-536924	22.1194
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	BMS-536924	82.685
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	GSK1904529A	39.141
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	Linsitinib	76.273
SIDM00543	SKCM\|melanoma	p.S522N (No)	GDSC	NVP-ADW742	6.7579
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-536924	43.4589
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-754807	1.4725
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	Linsitinib	4.5956
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	GSK1904529A	12.1224
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-536924	11.2126
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	BMS-536924	4.9349
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	GSK1904529A	34.907
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	Linsitinib	8.243
SIDM00954	BRCA\|breast	p.Y517C (No)	GDSC	NVP-ADW742	2.7905
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-536924	7.4357
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-754807	4.6615
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	Linsitinib	12.1847
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	GSK1904529A	7.2173
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-536924	2.5812
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	BMS-536924	10.902
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	GSK1904529A	88.947
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	Linsitinib	28.507
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.L17V (No)	GDSC	NVP-ADW742	7.2883
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-536924	7.4357
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-754807	4.6615
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	Linsitinib	12.1847
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	GSK1904529A	7.2173
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-536924	2.5812
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	BMS-536924	10.902
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	GSK1904529A	88.947
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	Linsitinib	28.507
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.Y58F (No)	GDSC	NVP-ADW742	7.2883
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-536924	7.4357
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-754807	4.6615
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	Linsitinib	12.1847
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	GSK1904529A	7.2173
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-536924	2.5812
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	BMS-536924	10.902
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	GSK1904529A	88.947
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	Linsitinib	28.507
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.M186L (No)	GDSC	NVP-ADW742	7.2883
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-536924	1.8411
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-754807	14.1186
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	Linsitinib	16.9354
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	GSK1904529A	9.4919
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-536924	4.2668
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	BMS-536924	2.6318
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	GSK1904529A	164.76
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	Linsitinib	26.557
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.T677I (No)	GDSC	NVP-ADW742	6.2857
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-754807	6.9258
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	Linsitinib	40.5989
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	GSK1904529A	12.1109
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-536924	22.1767
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-536924	6.3692
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	GSK1904529A	39.342
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	Linsitinib	27.639
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	NVP-ADW742	7.9187
SIDM00789	COREAD\|large_intestine	p.N792D (No)	GDSC	BMS-754807	2.0375
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-754807	6.9258
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	Linsitinib	40.5989
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	GSK1904529A	12.1109
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-536924	22.1767
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-536924	6.3692
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	GSK1904529A	39.342
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	Linsitinib	27.639
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	NVP-ADW742	7.9187
SIDM00789	COREAD\|large_intestine	p.R1246C (No)	GDSC	BMS-754807	2.0375
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-536924	93.0482
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-754807	25.2865
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	Linsitinib	106.4328
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	GSK1904529A	9.5272
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-536924	108.1201
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	BMS-536924	130.19
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	GSK1904529A	131.98
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	Linsitinib	534.88
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.S1009L (No)	GDSC	NVP-ADW742	369.56
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	BMS-754807	0.4216
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	Linsitinib	1.3624
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	GSK1904529A	11.8814
SIDM00493	UNCLASSIFIED\|lung_NSCLC_adenocarcinoma	p.D1341N (No)	GDSC	BMS-536924	0.5462
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	BMS-754807	0.1555
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	Linsitinib	2.6669
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	GSK1904529A	3.0317
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	BMS-536924	40.6424
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	BMS-536924	13.706
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	GSK1904529A	68.897
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	Linsitinib	59.554
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E1289* (No)	GDSC	NVP-ADW742	23.938
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	BMS-754807	29.2901
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	Linsitinib	45.516
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	GSK1904529A	13.0642
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	BMS-536924	28.9113
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	BMS-536924	54.915
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	GSK1904529A	172.51
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	Linsitinib	486.96
SIDM00545	SKCM\|melanoma	p.P989S (No)	GDSC	NVP-ADW742	13.102
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	BMS-754807	1.4257
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	Linsitinib	10.7654
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	GSK1904529A	10.0918
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	BMS-536924	4.8645
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	BMS-536924	16.527
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	GSK1904529A	198.37
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	Linsitinib	40.236
SIDM00708	LUAD\|lung_NSCLC_adenocarcinoma	p.G410V (No)	GDSC	NVP-ADW742	23.323
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-536924	3.7247
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-754807	1.6574
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	Linsitinib	8.9124
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	GSK1904529A	2.9679
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-536924	14.5536
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	BMS-536924	6.3355
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	GSK1904529A	14.63
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	Linsitinib	18.752
SIDM00985	UNCLASSIFIED\|Burkitt_lymphoma	p.V554M (No)	GDSC	NVP-ADW742	6.1878
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-536924	0.3417
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-754807	0.4477
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	Linsitinib	1.2654
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	GSK1904529A	15.173
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-536924	3.9509
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	BMS-536924	1.0331
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	GSK1904529A	76.283
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	Linsitinib	21.166
SIDM00759	LUAD\|lung_NSCLC_adenocarcinoma	p.E1037K (No)	GDSC	NVP-ADW742	13.251
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	BMS-754807	1.0929
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	Linsitinib	16.7882
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	GSK1904529A	4.2689
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	BMS-536924	4.6204
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	BMS-536924	10.969
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	GSK1904529A	31.544
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	Linsitinib	86.74
SIDM00373	UCEC\|endometrium	p.R252C (No)	GDSC	NVP-ADW742	80.25
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-536924	12.7461
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-754807	1.3258
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	Linsitinib	16.0193
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	GSK1904529A	8.322
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-536924	17.8002
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	BMS-536924	41.504
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	GSK1904529A	34.246
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	Linsitinib	93.281
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R279H (No)	GDSC	NVP-ADW742	178.58
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	BMS-754807	13.4241
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	Linsitinib	57.9789
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	GSK1904529A	22.5694
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	BMS-536924	62.2515
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	BMS-536924	74.056
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	GSK1904529A	231.15
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	Linsitinib	232.75
SIDM00761	SCLC\|lung_small_cell_carcinoma	p.E302K (No)	GDSC	NVP-ADW742	177.07
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	BMS-754807	2.5001
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	Linsitinib	23.8447
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	GSK1904529A	8.0548
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	BMS-536924	10.3394
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	BMS-536924	47.625
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	GSK1904529A	169.4
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	Linsitinib	253.15
SIDM00120	PRAD\|prostate	p.G912fs*26 (No)	GDSC	NVP-ADW742	108.28
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	BMS-536924	12.5028
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	BMS-536924	0.443
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	GSK1904529A	72.08
SIDM01005	LAML\|acute_myeloid_leukaemia	p.T104M (No)	GDSC	Linsitinib	14.861
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-754807	0.1226
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	Linsitinib	1.8852
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	GSK1904529A	7.4587
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-536924	5.2043
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-536924	5.8179
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	GSK1904529A	21.883
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	Linsitinib	40.694
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	NVP-ADW742	11.596
SIDM00537	COREAD\|large_intestine	p.Y201H (No)	GDSC	BMS-754807	1.0155
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-754807	0.1226
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	Linsitinib	1.8852
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	GSK1904529A	7.4587
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-536924	5.2043
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-536924	5.8179
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	GSK1904529A	21.883
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	Linsitinib	40.694
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	NVP-ADW742	11.596
SIDM00537	COREAD\|large_intestine	p.D435G (No)	GDSC	BMS-754807	1.0155
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-754807	0.4783
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	Linsitinib	11.8142
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	GSK1904529A	12.4574
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-536924	0.7393
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-536924	0.5696
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	GSK1904529A	342.82
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	Linsitinib	2.6963
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	NVP-ADW742	1.8121
SIDM00837	COREAD\|large_intestine	p.A828T (No)	GDSC	BMS-754807	0.0528
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-536924	9.0589
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-754807	0.7653
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	Linsitinib	2.7472
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	GSK1904529A	9.1054
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-536924	1.1087
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	BMS-536924	5.9473
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	GSK1904529A	55.744
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	Linsitinib	8.8272
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.V259I (No)	GDSC	NVP-ADW742	3.8583
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-536924	9.0589
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-754807	0.7653
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	Linsitinib	2.7472
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	GSK1904529A	9.1054
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-536924	1.1087
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	BMS-536924	5.9473
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	GSK1904529A	55.744
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	Linsitinib	8.8272
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.T758M (No)	GDSC	NVP-ADW742	3.8583
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	BMS-754807	2.5279
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	Linsitinib	34.4248
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	GSK1904529A	6.3395
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	BMS-536924	5.1217
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	GSK1904529A	61.114
SIDM00043	HNSC\|head_and_neck	p.R650Q (No)	GDSC	Linsitinib	76.594
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	BMS-754807	1.9847
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	Linsitinib	6.0608
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	GSK1904529A	13.5024
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	BMS-536924	1.3757
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	BMS-536924	18.627
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	GSK1904529A	113.54
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	Linsitinib	112.28
SIDM00679	CESC\|cervix	p.K339N (No)	GDSC	NVP-ADW742	252.29
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	BMS-536924	51.2628
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	GSK1904529A	120.43
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	Linsitinib	84.967
SIDM00193	COREAD\|large_intestine	p.F777L (No)	GDSC	BMS-754807	31.752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQSST

Degron related mutations and impact score

Drug responses associated with IGF1R mutations

All proteins holding degron of PQSST