DegronMD - Q93052(LPP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E132D	TCGA-18-3417	LUSC	TCGA	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0556
p.E132D	DO26584	LUSC	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0556
p.G147R	TCGA-85-7843	LUSC	TCGA	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.G147R	DO26500	LUSC	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.S227L	TCGA-98-8021	LUSC	TCGA	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation blocking phosphorylation signal	0.5
p.S227L	DO27468	LUSC	ICGC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation blocking phosphorylation signal	0.5
p.S155L	TCGA-B5-A3FA	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.S155L	DO52402	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.S135Y	TCGA-BF-A5EQ	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.5833
p.S135Y	DO219452	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.5833
p.S227A	TCGA-CR-5248	HNSC	TCGA	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation blocking phosphorylation signal	0.5
p.S227A	DO14694	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation blocking phosphorylation signal	0.5
p.S217L	TCGA-FD-A3SS	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7667
p.S217L	DO737	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7667
p.S151C	TCGA-PE-A5DE	BRCA	TCGA	PQSST	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.6389
p.S151C	DO219643	BRCA	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.6389
p.Y137C	TCGA-V1-A9Z7	PRAD	TCGA	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.Y137C	DO219391	PRAD	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1944
p.C133F	DO228952	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.0833
p.G147C	DO229038	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.3056
p.V206L	DO227567	ORCA	ICGC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.P139H	DO49478	PACA	ICGC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.25
p.S209F	DO229462	SKCA	ICGC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.2222
p.A208T	DO231498	THCA	ICGC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1944
p.P136S	SIDM00614	Hepatocellular Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	SIDM00581	Glioblastoma	GDSC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	GB-1	central nervous system	COSMIC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P136S	JHH-7	liver	COSMIC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.1667
p.P207L	SIDM01248	Thyroid Gland Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.P207L	SIDM01167	Thyroid Gland Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.V206F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.V206F	ACH-000951	Lung Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.V206F	NCI-H2342	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1389
p.S151P	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.6389
p.S148L	ACH-001982	Metastasis	CCLE	PQSST	DEG_SPOP_SBC_1	142:146	Mutation rewiring degron network	0.2778
p.T151R	CS1	bone	COSMIC	PQSST	DEG_SPOP_SBC_1	142:146	Mutation blocking phosphorylation signal	0.6389
p.M213K	KYSE-180	oesophagus	COSMIC	ASTSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.8062

Kaplan plot for LPP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LPP

UniProt ID: Q93052

Entrez ID: 4026

Protein name: Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LPP in