DegronMD

Uniprot ID: Q93052

Source protein: Lipoma-preferred partner

Source gene: LPP

Class: DEG_SPOP_SBC_1

Location: 142:146

E3 ligase: SPOP

DEGRON score: 0.9235

ASA_SCORE: 93.72

COIL: 0.9508

CONS_SCORE: 0.328

DSS_SCORE: 0.7453

HELIX: 0.0288

FCONS_SCORE: 0.901

RIG_SCORE: 0.505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E132D	TCGA-18-3417	LUSC	TCGA	PQSST	DEG_SPOP_SBC_1	0.0556
p.E132D	DO26584	LUSC	ICGC	PQSST	DEG_SPOP_SBC_1	0.0556
p.G147R	TCGA-85-7843	LUSC	TCGA	PQSST	DEG_SPOP_SBC_1	0.3056
p.G147R	DO26500	LUSC	ICGC	PQSST	DEG_SPOP_SBC_1	0.3056
p.S155L	TCGA-B5-A3FA	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.0833
p.S155L	DO52402	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.0833
p.S135Y	TCGA-BF-A5EQ	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	0.5833
p.S135Y	DO219452	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	0.5833
p.S151C	TCGA-PE-A5DE	BRCA	TCGA	PQSST	DEG_SPOP_SBC_1	0.6389
p.S151C	DO219643	BRCA	ICGC	PQSST	DEG_SPOP_SBC_1	0.6389
p.Y137C	TCGA-V1-A9Z7	PRAD	TCGA	PQSST	DEG_SPOP_SBC_1	0.1944
p.Y137C	DO219391	PRAD	ICGC	PQSST	DEG_SPOP_SBC_1	0.1944
p.C133F	DO228952	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.0833
p.G147C	DO229038	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	0.3056
p.P139H	DO49478	PACA	ICGC	PQSST	DEG_SPOP_SBC_1	0.25
p.P136S	SIDM00614	Hepatocellular Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.1667
p.P136S	SIDM00581	Glioblastoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.1667
p.P136S	GB-1	central_nervous_system	COSMIC	PQSST	DEG_SPOP_SBC_1	0.1667
p.P136S	JHH-7	liver	COSMIC	PQSST	DEG_SPOP_SBC_1	0.1667
p.S151P	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.6389
p.S148L	ACH-001982	Metastasis	CCLE	PQSST	DEG_SPOP_SBC_1	0.2778
p.T151R	CS1	bone	COSMIC	PQSST	DEG_SPOP_SBC_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons