DegronMD

Uniprot ID: Q2KHR3

Source protein: Glutamine and serine-rich protein 1

Source gene: QSER1

Class: DEG_SPOP_SBC_1

Location: 129:133

E3 ligase: SPOP

DEGRON score: 0.9614

ASA_SCORE: 95.76

COIL: 0.9454

CONS_SCORE: 0.7544

DSS_SCORE: 0.5416

HELIX: 0.0322

FCONS_SCORE: 1.1155

RIG_SCORE: 0.6347

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S140Y	TCGA-AX-A06F	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	0.1389
p.S140Y	DO41752	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	SIDM00845	Burkitt's Lymphoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	SIDM00461	Acute Myeloid Leukemia	GDSC	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	SIDM01519	Head and Neck Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	ACH-000786	Lymphoma	CCLE	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	ACH-000992	Head and Neck Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.1389
p.V122A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	0.1389
p.I127V	SIDM00845	Burkitt's Lymphoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.2778
p.I127V	SIDM00461	Acute Myeloid Leukemia	GDSC	PQSST	DEG_SPOP_SBC_1	0.2778
p.I127V	SIDM01519	Head and Neck Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.2778
p.I127V	ACH-000786	Lymphoma	CCLE	PQSST	DEG_SPOP_SBC_1	0.2778
p.I127V	ACH-000992	Head and Neck Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.2778
p.I127V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQSST	DEG_SPOP_SBC_1	0.2778
p.Y134C	SIDM01608	Endometrial Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	0.3056
p.Y134C	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14964	Hepatocyte growth factor-regulated tyrosine kinase substrate	DEG_SPOP_SBC_1	689:693	PQSST	SPOP	0.9823	More...
O15062	Zinc finger and BTB domain-containing protein 5	DEG_SPOP_SBC_1	382:386	PQSST	SPOP	0.9983	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1362:1366	PQSST	SPOP	0.9661	More...
Q01844	RNA-binding protein EWS	DEG_SPOP_SBC_1	151:155	PQSST	SPOP	0.8757	More...
Q86XJ1	GAS2-like protein 3	DEG_SPOP_SBC_1	619:623	PQSST	SPOP	0.9841	More...
Q93052	Lipoma-preferred partner	DEG_SPOP_SBC_1	142:146	PQSST	SPOP	0.9235	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	21:25	PQSST	SPOP	0.9781	More...
P63132	Endogenous retrovirus group K member 113 Pol protein	DEG_SPOP_SBC_1	875:879	PQSST	SPOP	0.8663	More...
P63136	Endogenous retrovirus group K member 25 Pol protein	DEG_SPOP_SBC_1	873:877	PQSST	SPOP	0.5968	More...
Q9ULK2	Ataxin-7-like protein 1	DEG_SPOP_SBC_1	647:651	PQSST	SPOP	0.9761	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	129:133	PQSST	SPOP	0.9614	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons