DegronMD - Q9UQR0(SCML2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L585Q	TCGA-17-Z017	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.H596L	TCGA-49-4506	LUAD	TCGA	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.0556
p.H596L	DO25084	LUAD	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.0556
p.D31Y	TCGA-55-8508	LUAD	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1667
p.D31Y	DO45341	LUAD	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1667
p.D588Y	TCGA-A5-A0G2	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.D588Y	DO41235	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.R471M	TCGA-AA-3818	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.R471M	DO7792	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.A613T	TCGA-AJ-A3OL	UCEC	TCGA	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation altering degron motif	0.6028
p.A613T	DO43001	UCEC	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation altering degron motif	0.6028
p.V28I	TCGA-AN-A0AK	BRCA	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.25
p.V28I	DO1608	BRCA	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.25
p.P617H	TCGA-AP-A056	UCEC	TCGA	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation altering degron motif	0.7694
p.P617H	DO43971	UCEC	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation altering degron motif	0.7694
p.V569F	TCGA-AX-A1C7	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.V569F	DO41115	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.N460H	TCGA-AX-A2HC	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1667
p.N460H	DO41572	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1667
p.D31H	TCGA-B0-5099	KIRC	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1667
p.D31H	DO16317	KIRC	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1667
p.G579D	TCGA-B5-A0JY	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.6087
p.G579D	DO43041	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.6087
p.V577A	TCGA-BR-6452	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.V577A	DO38404	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.K626N	TCGA-BS-A0UV	UCEC	TCGA	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation substituting flanking lysine	0.1944
p.K626N	DO42793	UCEC	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation substituting flanking lysine	0.1944
p.Q22K	TCGA-CV-7091	HNSC	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.5833
p.Q22K	DO14212	HNSC	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.5833
p.Q22K	DO229045	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.5833
p.H475Q	TCGA-D3-A2JE	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1944
p.H475Q	DO219476	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1944
p.D572N	TCGA-DA-A1HW	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.D572N	TCGA-FR-A726	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.D572N	DO48665	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.D572N	DO38129	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.L585I	TCGA-E9-A22B	BRCA	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.L585I	DO1454	BRCA	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.25
p.D627A	TCGA-EE-A2A2	SKCM	TCGA	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.0556
p.D627A	DO37583	SKCM	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.0556
p.D32N	TCGA-EE-A3JI	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1389
p.D32N	DO47268	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1389
p.S26Y	TCGA-EO-A3B0	UCEC	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.3056
p.S26Y	DO219773	UCEC	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.3056
p.G587V	TCGA-ER-A19N	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.G587V	DO37452	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.S26F	TCGA-FR-A726	SKCM	TCGA	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.3056
p.S26F	DO48665	SKCM	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.3056
p.G587W	TCGA-GN-A265	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.G587W	DO37491	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.V586F	TCGA-LA-A446	LUSC	TCGA	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.V586F	DO45450	LUSC	ICGC	PGTTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.S470F	TCGA-W3-AA1V	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7982
p.S470F	DO51276	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7982
p.G472D	DO233652	GACA	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2778
p.P617T	DO229029	LICA	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation altering degron motif	0.7031
p.F33L	DO229037	LICA	ICGC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1111
p.L461V	DO228394	MALY	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1944
p.S606R	DO220849	MELA	ICGC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation altering degron motif	0.8538
p.H480N	DO50705	ORCA	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.G472V	DO229208	THCA	ICGC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2778
p.S625C	SIDM00845	Burkitt's Lymphoma	GDSC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.1111
p.S625C	SIDM00461	Acute Myeloid Leukemia	GDSC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.1111
p.S625C	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.1111
p.S625C	ACH-000786	Lymphoma	CCLE	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.1111
p.S625C	ACH-000992	Head and Neck Cancer	CCLE	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.1111
p.S625C	Daudi	haematopoietic and lymphoid tissue	COSMIC	SEAPSYIAVPDP	DEG_COP1_1	606:617	Mutation rewiring degron network	0.1111
p.S464C	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2778
p.S464C	ACH-000697	Lymphoma	CCLE	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2778
p.S464C	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2778
p.Q17K	SIDM00619	Thyroid Gland Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.2222
p.Q17K	ACH-002397	Thyroid Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.2222
p.Q17K	KMH-2	thyroid	COSMIC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.2222
p.V12A	SIDM00217	Colorectal Carcinoma	GDSC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.V12A	ACH-000999	Colon/Colorectal Cancer	CCLE	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.V12A	SNU-1040	large intestine	COSMIC	PQSST	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.S469Y	SIDM00118	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.712
p.S469Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.712
p.S469Y	HCC2998	large intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.712
p.S468I	ACH-000455	Brain Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7341

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCML2

UniProt ID: Q9UQR0

Entrez ID: 10389

Protein name: Sex comb on midleg-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCML2 in