DegronMD

Uniprot ID: Q9UQR0

Source protein: Sex comb on midleg-like protein 2

Source gene: SCML2

Class: DEG_SPOP_SBC_1

Location: 578:582

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 73.76

COIL: 0.9402

CONS_SCORE: 0.6851

DSS_SCORE: 0.541

HELIX: 0.0188

FCONS_SCORE: 1.0083

RIG_SCORE: 0.5958

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L585Q	TCGA-17-Z017	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.25
p.D588Y	TCGA-A5-A0G2	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1667
p.D588Y	DO41235	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.V569F	TCGA-AX-A1C7	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0833
p.V569F	DO41115	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.G579D	TCGA-B5-A0JY	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6087
p.G579D	DO43041	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6087
p.V577A	TCGA-BR-6452	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.3056
p.V577A	DO38404	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.D572N	TCGA-DA-A1HW	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1667
p.D572N	TCGA-FR-A726	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1667
p.D572N	DO48665	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.D572N	DO38129	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.L585I	TCGA-E9-A22B	BRCA	TCGA	PGTTS	DEG_SPOP_SBC_1	0.25
p.L585I	DO1454	BRCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.25
p.G587V	TCGA-ER-A19N	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1944
p.G587V	DO37452	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1944
p.G587W	TCGA-GN-A265	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1944
p.G587W	DO37491	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1944
p.V586F	TCGA-LA-A446	LUSC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2222
p.V586F	DO45450	LUSC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons