DegronMD

Uniprot ID: Q9UQ35

Source protein: Serine/arginine repetitive matrix protein 2

Source gene: SRRM2

Class: DEG_SPOP_SBC_1

Location: 313:317

E3 ligase: SPOP

DEGRON score: 0.9196

ASA_SCORE: 86.92

COIL: 0.9592

CONS_SCORE: 0.3773

DSS_SCORE: 0.8525

HELIX: 0.0242

FCONS_SCORE: 0.944

RIG_SCORE: 0.5205

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A308V	TCGA-A5-A1OF	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1944
p.A308V	DO42568	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1944
p.R303H	TCGA-A6-2686	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R303H	DO7828	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R303H	DO228546	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.G304R	TCGA-CG-5723	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0833
p.G304R	DO38376	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.R320Q	TCGA-EO-A22U	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.25
p.R320Q	DO43755	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.25
p.P324Q	TCGA-GN-A26D	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.P324Q	DO37480	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.P309T	DO233089	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.R303L	DO229035	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.E305D	DO232048	ORCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.S311G	SIDM00032	Bladder Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7222
p.S311G	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7222
p.S311G	SIDM00785	Acute Myeloid Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7222
p.S311G	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7222
p.S311G	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.7222
p.A327V	NCI-H630	large_intestine	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons