DegronMD

Uniprot ID: A6NDV4

Source protein: Transmembrane protein 8B

Source gene: TMEM8B

Class: DEG_SPOP_SBC_1

Location: 26:30

E3 ligase: SPOP

DEGRON score: 0.948

ASA_SCORE: 73.72

COIL: 0.9426

CONS_SCORE: 0.3295

DSS_SCORE: 0.6735

HELIX: 0.0186

FCONS_SCORE: 0.9333

RIG_SCORE: 0.4952

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P22H	TCGA-AZ-6601	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2222
p.P22H	DO8119	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.G27W	TCGA-EE-A29G	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6714
p.G27W	DO47303	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6714
p.P22L	DO222753	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.R39C	SIDM02021	Esophageal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.L19P	SIDM00752	Non-Cancerous	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.L19P	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons