DegronMD - A6NDV4(TMEM8B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L75P	TCGA-AP-A1DK	UCEC	TCGA	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1944
p.L75P	DO42033	UCEC	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1944
p.P22H	TCGA-AZ-6601	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.2222
p.P22H	DO8119	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.2222
p.A93V	TCGA-BR-4201	STAD	TCGA	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1389
p.A93V	DO38707	STAD	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1389
p.A93V	DO41199	UCEC	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1389
p.R74G	TCGA-DI-A1BU	UCEC	TCGA	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1667
p.R74G	DO42023	UCEC	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1667
p.G27W	TCGA-EE-A29G	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation altering degron motif	0.6714
p.G27W	DO47303	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation altering degron motif	0.6714
p.V84A	DO222856	COCA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation altering degron motif	0.5825
p.E88D	DO228377	LICA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.2778
p.A72S	DO229028	LICA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1111
p.P22L	DO222753	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.2222
p.L91F	DO232761	PBCA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1944
p.A72T	DO229224	THCA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.1111
p.R39C	SIDM02021	Esophageal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.0833
p.V96L	SIDM00572	Gastric Carcinoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	SIDM00324	Neuroblastoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	TK	haematopoietic and lymphoid tissue	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	NUGC-3	stomach	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	TGW	autonomic ganglia	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96L	PC-14	lung	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96M	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96M	ACH-002272	Lymphoma	CCLE	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.V96M	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation rewiring degron network	0.0556
p.L19P	SIDM00752	Non-Cancerous	GDSC	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1389
p.L19P	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1389
p.V84I	ACH-000829	Myeloma	CCLE	DSGGVLS	DEG_SCF_TRCP1_1	80:86	Mutation altering degron motif	0.5965

Kaplan plot for TMEM8B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM8B

UniProt ID: A6NDV4

Entrez ID: 51754

Protein name: Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM8B in