DegronMD

Uniprot ID: A6NDV4

Source protein: Transmembrane protein 8B

Source gene: TMEM8B

Class: DEG_SCF_TRCP1_1

Location: 80:86

E3 ligase: BTRC

DEGRON score: 0.5266

ASA_SCORE: 34.5429

COIL: 0.3301

CONS_SCORE: 0.5905

DSS_SCORE: 0.0416

HELIX: 0.0154

FCONS_SCORE: 1.508

RIG_SCORE: 0.7992

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V84I	ACH-000829	Myeloma	CCLE	DSGGVLS	DEG_SCF_TRCP1_1	0.5965
p.V84A	DO222856	COCA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.5825
p.E88D	DO228377	LICA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.2778
p.L75P	TCGA-AP-A1DK	UCEC	TCGA	DSGGVLS	DEG_SCF_TRCP1_1	0.1944
p.L75P	DO42033	UCEC	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1944
p.L91F	DO232761	PBCA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1944
p.R74G	TCGA-DI-A1BU	UCEC	TCGA	DSGGVLS	DEG_SCF_TRCP1_1	0.1667
p.R74G	DO42023	UCEC	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1667
p.A93V	TCGA-BR-4201	STAD	TCGA	DSGGVLS	DEG_SCF_TRCP1_1	0.1389
p.A93V	DO38707	STAD	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1389
p.A93V	DO41199	UCEC	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1389
p.A72S	DO229028	LICA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1111
p.A72T	DO229224	THCA	ICGC	DSGGVLS	DEG_SCF_TRCP1_1	0.1111
p.V96L	SIDM00572	Gastric Carcinoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	SIDM00324	Neuroblastoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	TK	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	NUGC-3	stomach	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	TGW	autonomic_ganglia	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96L	PC-14	lung	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96M	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96M	ACH-002272	Lymphoma	CCLE	DSGGVLS	DEG_SCF_TRCP1_1	0.0556
p.V96M	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGGVLS	DEG_SCF_TRCP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SCF_TRCP1_1	80:86	DSGGVLS	BTRC	0.5266	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons