DegronMD - Q8NFW1(COL22A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1500W	TCGA-06-0686	GBM	TCGA	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.0833
p.G1500W	DO13348	GBM	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.0833
p.A1490E	TCGA-17-Z021	LUAD	TCGA	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.659
p.A1490E	DO228862	LICA	ICGC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.659
p.T854I	TCGA-17-Z042	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7078
p.P1489T	TCGA-17-Z045	LUAD	TCGA	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7031
p.T1478S	TCGA-30-1855	OV	TCGA	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.0556
p.T1478S	DO32666	OV	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.0556
p.P864H	TCGA-55-7574	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.P864H	DO229006	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.P864H	DO23986	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.Q1496E	TCGA-55-7903	LUAD	TCGA	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.S855F	TCGA-A2-A0CR	BRCA	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7982
p.S855F	DO44163	BRCA	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7982
p.R862W	TCGA-AA-3861	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.R862W	DO9562	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.R862W	DO233898	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.S1495Y	TCGA-AA-A010	COAD	TCGA	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.2222
p.G464S	TCGA-B0-4712	KIRC	TCGA	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation altering degron motif	0.5882
p.G464S	DO16530	KIRC	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation altering degron motif	0.5882
p.G464S	ACH-000915	Skin Cancer	CCLE	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation altering degron motif	0.5882
p.G464S	IPC-298	skin	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation altering degron motif	0.5882
p.P1489L	TCGA-BH-A0DZ	BRCA	TCGA	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7582
p.P1489L	TCGA-E7-A3Y1	BLCA	TCGA	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7582
p.P1489L	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7582
p.P1489L	ACH-000953	Leukemia	CCLE	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7582
p.P1489L	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7582
p.P455L	TCGA-D3-A3MV	SKCM	TCGA	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1944
p.P455L	DO37727	SKCM	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1944
p.P847S	TCGA-D3-A8GM	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2222
p.P847S	TCGA-R6-A6XQ	ESCA	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2222
p.P847S	DO50288	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.2222
p.L850V	TCGA-D7-6822	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.L850V	DO38423	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.3056
p.P851S	TCGA-D9-A1JX	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.6752
p.P851S	DO37711	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.6752
p.P1488S	TCGA-DA-A95Z	SKCM	TCGA	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.6752
p.P1488S	DO219481	SKCM	ICGC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.6752
p.G469W	TCGA-EB-A299	SKCM	TCGA	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.25
p.G469W	DO37794	SKCM	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.25
p.L1483I	TCGA-FI-A2D5	UCEC	TCGA	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.A1490T	TCGA-FS-A4FC	SKCM	TCGA	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.6028
p.A1490T	DO37762	SKCM	ICGC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.6028
p.P454Q	TCGA-NF-A4X2	UCS	TCGA	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1667
p.M863I	TCGA-OR-A5KB	ACC	TCGA	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1111
p.Q1496K	DO4557	BRCA	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.M1497I	DO229003	COCA	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1667
p.M1492I	DO234437	ESAD	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.3056
p.P864L	DO233276	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.P1500T	DO52078	HNSC	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.0833
p.P1500T	DO23352	LINC	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.0833
p.P460T	DO51008	LAML	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation altering degron motif	0.7031
p.P454T	DO228978	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1667
p.P1482Q	DO229029	LICA	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1667
p.P1482Q	DO50291	SKCM	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1667
p.P455T	DO229029	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1944
p.P455T	DO229037	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1944
p.P455T	DO229009	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1944
p.P844S	DO231724	LINC	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.E841K	DO23498	LINC	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0556
p.A842T	DO231204	LUSC	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.0833
p.P1484L	DO45482	LUSC	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.2222
p.T853N	DO32819	PACA	ICGC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7055
p.T853N	SIDM01136	Pancreatic Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7055
p.T853N	PANC-08-13	pancreas	COSMIC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.7055
p.G1495S	DO220003	SARC	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.2222
p.G1495S	DO47767	STAD	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.2222
p.G1498W	DO47509	SKCM	ICGC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1389
p.S855Y	SIDM01156	Small Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.712
p.S855Y	ACH-000890	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation altering degron motif	0.712
p.L1483H	SIDM01119	Other Solid Cancers	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM01245	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00631	Breast Carcinoma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00948	Burkitt's Lymphoma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00379	Glioma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM01229	Neuroblastoma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM01205	Acute Myeloid Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM01613	Colorectal Carcinoma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM01195	Acute Myeloid Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM01590	Breast Carcinoma	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.L1483H	SIDM00991	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	1488:1491	Mutation rewiring degron network	0.1944
p.R862L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.R862L	ACH-000665	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.R862L	SK-MES-1	lung	COSMIC	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1389
p.P1489Q	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7035
p.P1489Q	ACH-000886	Lung Cancer	CCLE	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7035
p.P1489Q	NCI-H2009	lung	COSMIC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.7035
p.G846D	ACH-000512	Myeloma	CCLE	PGTTS	DEG_SPOP_SBC_1	851:855	Mutation rewiring degron network	0.1944
p.Q458P	ACH-000866	Lung Cancer	CCLE	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.2778
p.Q458P	NCI-H1048	lung	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.2778
p.S465R	ACH-000975	Lung Cancer	CCLE	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation altering degron motif	0.6316
p.P458H	NCI-H1688	lung	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.2778
p.F452I	G-401	soft tissue	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1111
p.A1490V	GRANTA-519	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.5825
p.A1490V	Caov-4	ovary	COSMIC	PPAY	ITCH	1488:1491	Mutation altering degron motif	0.5825
p.P453Q	NCI-H1666	lung	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1389
p.P474R	MDA-MB-453	breast	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	460:466	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

COL22A1

UniProt ID: Q8NFW1

Entrez ID: 169044

Protein name: Collagen alpha-1(XXII) chain

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for COL22A1 in