DegronMD

Uniprot ID: Q8NFW1

Source protein: Collagen alpha-1

Source gene: COL22A1

Class: DEG_SCF_FBW7_2

Location: 460:466

E3 ligase: FBXW7

DEGRON score: 0.9202

ASA_SCORE: 78.7571

COIL: 0.9284

CONS_SCORE: 0.3837

DSS_SCORE: 0.7758

HELIX: 0.0456

FCONS_SCORE: 0.9112

RIG_SCORE: 0.5852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G464S	TCGA-B0-4712	KIRC	TCGA	PPTPGSE	DEG_SCF_FBW7_2	0.5882
p.G464S	DO16530	KIRC	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.5882
p.G464S	ACH-000915	Skin Cancer	CCLE	PPTPGSE	DEG_SCF_FBW7_2	0.5882
p.G464S	IPC-298	skin	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	0.5882
p.P455L	TCGA-D3-A3MV	SKCM	TCGA	PPTPGSE	DEG_SCF_FBW7_2	0.1944
p.P455L	DO37727	SKCM	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.1944
p.G469W	TCGA-EB-A299	SKCM	TCGA	PPTPGSE	DEG_SCF_FBW7_2	0.25
p.G469W	DO37794	SKCM	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.25
p.P454Q	TCGA-NF-A4X2	UCS	TCGA	PPTPGSE	DEG_SCF_FBW7_2	0.1667
p.P460T	DO51008	LAML	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.7031
p.P454T	DO228978	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.1667
p.P455T	DO229029	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.1944
p.P455T	DO229037	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.1944
p.P455T	DO229009	LICA	ICGC	PPTPGSE	DEG_SCF_FBW7_2	0.1944
p.Q458P	ACH-000866	Lung Cancer	CCLE	PPTPGSE	DEG_SCF_FBW7_2	0.2778
p.Q458P	NCI-H1048	lung	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	0.2778
p.S465R	ACH-000975	Lung Cancer	CCLE	PPTPGSE	DEG_SCF_FBW7_2	0.6316
p.P458H	NCI-H1688	lung	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	0.2778
p.F452I	G-401	soft_tissue	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	0.1111
p.P453Q	NCI-H1666	lung	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	0.1389
p.P474R	MDA-MB-453	breast	COSMIC	PPTPGSE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFW1	Collagen alpha-1	DEG_SCF_FBW7_2	460:466	PPTPGSE	FBXW7	0.9202	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons