DegronMD

Uniprot ID: Q9UGL1

Source protein: Lysine-specific demethylase 5B

Source gene: KDM5B

Class: DEG_SPOP_SBC_1

Location: 1308:1312

E3 ligase: SPOP

DEGRON score: 0.888

ASA_SCORE: 71.62

COIL: 0.9012

CONS_SCORE: 0.2718

DSS_SCORE: 0.5823

HELIX: 0.0422

FCONS_SCORE: 1.0268

RIG_SCORE: 0.6424

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1322K	TCGA-AA-3984	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R1322K	DO9002	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.V1298A	TCGA-AP-A1DK	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0556
p.V1298A	DO42033	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.G1309D	TCGA-B5-A11E	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6087
p.G1309D	DO41644	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6087
p.R1322G	TCGA-D1-A3JQ	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R1322G	DO219770	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.P1308S	TCGA-EE-A2A2	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6752
p.P1308S	DO37583	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6752
p.P1316L	TCGA-EE-A3JB	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2222
p.P1316L	DO51250	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.G1309C	TCGA-G7-6797	KIRP	TCGA	PGTTS	DEG_SPOP_SBC_1	0.6489
p.G1309C	DO20917	KIRP	ICGC	PGTTS	DEG_SPOP_SBC_1	0.6489
p.D1300E	DO228978	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.D1320E	DO229018	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.S1312L	DO222363	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7667
p.S1312L	ACH-000727	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.7667
p.S1312L	NCI-H2066	lung	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.7667
p.S1307L	SIDM00193	Colorectal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.S1307L	SNU-81	large_intestine	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.S1320A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.S1320A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons