DegronMD - Q9UGL1(KDM5B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1322K	TCGA-AA-3984	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.0556
p.R1322K	DO9002	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.0556
p.V1298A	TCGA-AP-A1DK	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.0556
p.V1298A	DO42033	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.0556
p.R258H	TCGA-AR-A250	BRCA	TCGA	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1944
p.R258H	DO1802	BRCA	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1944
p.G1309D	TCGA-B5-A11E	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.6087
p.G1309D	DO41644	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.6087
p.L256V	TCGA-BR-7716	STAD	TCGA	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1389
p.L256V	DO38675	STAD	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1389
p.N255S	TCGA-CV-7235	HNSC	TCGA	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1111
p.N255S	DO15102	HNSC	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1111
p.R258C	TCGA-CZ-5466	KIRC	TCGA	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1944
p.R258C	DO17927	KIRC	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1944
p.R1322G	TCGA-D1-A3JQ	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.0556
p.R1322G	DO219770	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.0556
p.P1308S	TCGA-EE-A2A2	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.6752
p.P1308S	DO37583	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.6752
p.P1316L	TCGA-EE-A3JB	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.2222
p.P1316L	DO51250	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.2222
p.G1309C	TCGA-G7-6797	KIRP	TCGA	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.6489
p.G1309C	DO20917	KIRP	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.6489
p.S272F	DO219723	CESC	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.2222
p.R258S	DO228948	LICA	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1944
p.D1300E	DO228978	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.1111
p.D1320E	DO229018	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.1111
p.K278Q	DO50869	LICA	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation blocking ubiquitination signal	0.5
p.S275I	DO50869	LICA	ICGC	PTPKCE	DEG_SCF_FBW7_2	263:268	Mutation rewiring degron network	0.1389
p.S1312L	DO222363	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.7667
p.S1312L	ACH-000727	Lung Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.7667
p.S1312L	NCI-H2066	lung	COSMIC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation altering degron motif	0.7667
p.S1307L	SIDM00193	Colorectal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.3056
p.S1307L	SNU-81	large intestine	COSMIC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.3056
p.S1320A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.1111
p.S1320A	HT	haematopoietic and lymphoid tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	1308:1312	Mutation rewiring degron network	0.1111

Kaplan plot for KDM5B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM5B

UniProt ID: Q9UGL1

Entrez ID: 10765

Protein name: Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM5B in