DegronMD

Uniprot ID: Q9UGL1

Source protein: Lysine-specific demethylase 5B

Source gene: KDM5B

Class: DEG_SCF_FBW7_2

Location: 263:268

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 86.15

COIL: 0.7487

CONS_SCORE: 0.2527

DSS_SCORE: 0.584

HELIX: 0.2203

FCONS_SCORE: 1.0923

RIG_SCORE: 0.6836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R258H	TCGA-AR-A250	BRCA	TCGA	PTPKCE	DEG_SCF_FBW7_2	0.1944
p.R258H	DO1802	BRCA	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.1944
p.L256V	TCGA-BR-7716	STAD	TCGA	PTPKCE	DEG_SCF_FBW7_2	0.1389
p.L256V	DO38675	STAD	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.1389
p.N255S	TCGA-CV-7235	HNSC	TCGA	PTPKCE	DEG_SCF_FBW7_2	0.1111
p.N255S	DO15102	HNSC	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.1111
p.R258C	TCGA-CZ-5466	KIRC	TCGA	PTPKCE	DEG_SCF_FBW7_2	0.1944
p.R258C	DO17927	KIRC	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.1944
p.S272F	DO219723	CESC	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.2222
p.R258S	DO228948	LICA	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.1944
p.K278Q	DO50869	LICA	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.5
p.S275I	DO50869	LICA	ICGC	PTPKCE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGL1	Lysine-specific demethylase 5B	DEG_SCF_FBW7_2	263:268	PTPKCE	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons