DegronMD

Uniprot ID: Q5TBA9

Source protein: Protein furry homolog

Source gene: FRY

Class: DEG_SPOP_SBC_1

Location: 1963:1967

E3 ligase: SPOP

DEGRON score: 0.8986

ASA_SCORE: 54.78

COIL: 0.8522

CONS_SCORE: 0.214

DSS_SCORE: 0.7206

HELIX: 0.065

FCONS_SCORE: 0.804

RIG_SCORE: 0.5895

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1975L	TCGA-09-2044	OV	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1111
p.R1975L	DO28923	OV	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.N1969Y	TCGA-17-Z031	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.2778
p.E1974V	TCGA-44-2656	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E1974V	DO26052	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E1974K	TCGA-AG-A002	READ	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E1974K	TCGA-D1-A15X	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1389
p.E1974K	DO43274	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1389
p.A1973D	TCGA-AY-6197	COAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1667
p.A1973D	DO9956	COAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.P1963Q	TCGA-D3-A2JO	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7035
p.P1963Q	DO47619	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7035
p.R1975W	TCGA-EO-A3AV	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	0.1111
p.R1975W	DO222817	BTCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.R1975W	DO52412	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1111
p.P1963L	TCGA-FP-A4BE	STAD	TCGA	PGTTS	DEG_SPOP_SBC_1	0.7582
p.P1963L	DO233253	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7582
p.P1963L	DO233903	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7582
p.P1963L	DO48016	STAD	ICGC	PGTTS	DEG_SPOP_SBC_1	0.7582
p.G1968S	DO49292	ALL	ICGC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.R1977Q	DO233254	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R1977Q	SIDM00151	Ovarian Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R1977Q	ACH-000966	Ovarian Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.0556
p.R1977Q	IGROV-1	ovary	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.G1968V	DO229028	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.3056
p.G1957R	DO229058	LICA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.A1971P	DO220891	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.2222
p.R1977W	DO232224	PBCA	ICGC	PGTTS	DEG_SPOP_SBC_1	0.0556
p.G1957E	SIDM00272	Breast Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.G1957E	ACH-000910	Breast Cancer	CCLE	PGTTS	DEG_SPOP_SBC_1	0.1667
p.G1957E	MDA-MB-453	breast	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.1667
p.L1967M	CAKI-1	kidney	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.711
p.G1956E	MDA-MB-453	breast	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.5833
p.R1976Q	IGROV-1	ovary	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.0833
p.R1955I	COLO-800	skin	COSMIC	PGTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NDV4	Transmembrane protein 8B	DEG_SPOP_SBC_1	26:30	PGTTS	SPOP	0.948	More...
P11831	Serum response factor	DEG_SPOP_SBC_1	273:277	PGTTS	SPOP	0.9973	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	2832:2836	PGTTS	SPOP	0.6952	More...
Q5TBA9	Protein furry homolog	DEG_SPOP_SBC_1	1963:1967	PGTTS	SPOP	0.8986	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1426:1430	PGTTS	SPOP	0.5627	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1591:1595	PGTTS	SPOP	0.9888	More...
Q8N0Y2	Zinc finger protein 444	DEG_SPOP_SBC_1	176:180	PGTTS	SPOP	0.5828	More...
Q8NFW1	Collagen alpha-1	DEG_SPOP_SBC_1	851:855	PGTTS	SPOP	0.8684	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SPOP_SBC_1	434:438	PGTTS	SPOP	0.9249	More...
Q9UGL1	Lysine-specific demethylase 5B	DEG_SPOP_SBC_1	1308:1312	PGTTS	SPOP	0.888	More...
Q9UKU6	Thyrotropin-releasing hormone-degrading ectoenzyme	DEG_SPOP_SBC_1	117:121	PGTTS	SPOP	0.9471	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1602:1606	PGTTS	SPOP	0.9335	More...
Q9UQ35	Serine/arginine repetitive matrix protein 2	DEG_SPOP_SBC_1	313:317	PGTTS	SPOP	0.9196	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	578:582	PGTTS	SPOP	0.9989	More...
Q96DN6	Methyl-CpG-binding domain protein 6	DEG_SPOP_SBC_1	462:466	PGTTS	SPOP	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTTS

Degron related mutations and impact score

Drug responses associated with FRY mutations

All proteins holding degron of PGTTS