DegronMD - Q9BQI5(SGIP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V333L	TCGA-05-5423	LUAD	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1944
p.S493R	TCGA-18-3421	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation blocking phosphorylation signal	0.5
p.E385K	TCGA-21-1083	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.0556
p.P320A	TCGA-22-4596	LUSC	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.25
p.P373L	TCGA-2L-AAQL	PAAD	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.6471
p.P373L	TCGA-61-2096	OV	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.6471
p.P373L	TCGA-AX-A2HA	UCEC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.6471
p.G433S	TCGA-2Y-A9GU	LIHC	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.G433S	TCGA-ER-A42K	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.G270E	TCGA-33-4538	LUSC	TCGA	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1389
p.A517E	TCGA-34-2604	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.Q380K	TCGA-34-5231	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1944
p.V422L	TCGA-39-5011	LUSC	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.25
p.P496L	TCGA-3N-A9WD	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.V370L	TCGA-43-2578	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.5654
p.R368H	TCGA-43-3394	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8244
p.R368H	TCGA-B5-A3FC	UCEC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8244
p.L500F	TCGA-44-4112	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.P363H	TCGA-55-5899	LUAD	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2222
p.S516I	TCGA-55-6968	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.P79H	TCGA-64-1676	LUAD	TCGA	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.25
p.A503D	TCGA-64-5778	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7793
p.I497T	TCGA-69-7978	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1667
p.I497T	TCGA-BT-A42C	BLCA	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1667
p.A501G	TCGA-69-7978	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.T506P	TCGA-75-7031	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7031
p.A409T	TCGA-77-8148	LUSC	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1389
p.A258S	TCGA-86-8672	LUAD	TCGA	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.6477
p.P271Q	TCGA-91-6836	LUAD	TCGA	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1111
p.P271Q	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1111
p.P271Q	ACH-000951	Lung Cancer	CCLE	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1111
p.P271Q	NCI-H2342	lung	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1111
p.A409E	TCGA-91-6840	LUAD	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1389
p.T506N	TCGA-98-8021	LUSC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7055
p.V334M	TCGA-A5-A0G2	UCEC	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1667
p.R368C	TCGA-A5-A1OF	UCEC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8301
p.R368C	SIDM00690	Head and Neck Carcinoma	GDSC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8301
p.P414L	TCGA-AC-A5XS	BRCA	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.2778
p.G359S	TCGA-AG-A002	READ	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1111
p.G94D	TCGA-AJ-A3OL	UCEC	TCGA	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.G94D	TCGA-AP-A1DV	UCEC	TCGA	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.G427E	TCGA-AP-A1DV	UCEC	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.G427E	TCGA-AP-A1DV	UCEC	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1111
p.S505N	TCGA-B5-A11E	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.7069
p.T512A	TCGA-B5-A3FA	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.E504K	TCGA-BA-5152	HNSC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.591
p.E504K	TCGA-VQ-A92D	STAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.591
p.S442F	TCGA-BF-A9VF	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.G362W	TCGA-BR-4368	STAD	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1944
p.E83G	TCGA-BS-A0UJ	UCEC	TCGA	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.6087
p.E83K	TCGA-C8-A8HP	BRCA	TCGA	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.591
p.I269T	TCGA-CD-8531	STAD	TCGA	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1667
p.P360L	TCGA-CV-7568	HNSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1389
p.P360L	TCGA-FS-A1ZZ	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1389
p.S319F	TCGA-DA-A1HV	SKCM	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation blocking phosphorylation signal	0.6667
p.S319T	TCGA-DQ-7592	HNSC	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation blocking phosphorylation signal	0.6667
p.G270R	TCGA-E5-A4U1	BLCA	TCGA	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1389
p.E331K	TCGA-EB-A3XC	SKCM	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.25
p.L376S	TCGA-EE-A3AF	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.3056
p.P357S	TCGA-EE-A3J5	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.0556
p.P367S	TCGA-ER-A193	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.5641
p.S514F	TCGA-ER-A19F	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.S514F	TCGA-FW-A3R5	SKCM	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.P434L	TCGA-ER-A2NC	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7582
p.P495T	TCGA-EW-A1J5	BRCA	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.S510L	TCGA-FI-A2D5	UCEC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.R408S	TCGA-FJ-A3ZE	BLCA	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1111
p.S424L	TCGA-FS-A4FC	SKCM	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.0556
p.S424L	TCGA-FS-A4FC	SKCM	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1944
p.G406R	TCGA-G4-6320	COAD	TCGA	PPTY	ITCH	416:419	Mutation rewiring degron network	0.0556
p.P320L	TCGA-G9-A9S4	PRAD	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.25
p.P320L	SIDM00985	Burkitt's Lymphoma	GDSC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.25
p.P320L	BL-41	haematopoietic and lymphoid tissue	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.25
p.P373S	TCGA-GF-A6C9	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.5641
p.G435E	TCGA-J4-A67M	PRAD	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.6087
p.T437N	TCGA-L4-A4E5	LUAD	TCGA	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7055
p.P329T	TCGA-MN-A4N4	LUAD	TCGA	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.A503G	TCGA-MP-A4TK	LUAD	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation altering degron motif	0.754
p.R502W	TCGA-OR-A5LJ	ACC	TCGA	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.3056
p.L267I	TCGA-UY-A78K	BLCA	TCGA	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2222
p.L271I	DO219031	BLCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1111
p.E253K	DO219024	BLCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.25
p.R412S	DO484	BLCA	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.2222
p.D333G	DO227941	BRCA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1944
p.S428L	DO228452	BRCA	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1667
p.S428L	DO228452	BRCA	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.0833
p.S428L	DO37762	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1667
p.S428L	DO37762	SKCM	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.0833
p.P418L	DO50023	BRCA	ICGC	PPTY	ITCH	416:419	Mutation altering degron motif	0.7582
p.P262T	DO1707	BRCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7031
p.A313E	DO1434	BRCA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.0556
p.P262S	DO2216	BRCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.6752
p.G314W	DO5326	BRCA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.0833
p.E87K	DO219621	BRCA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.7022
p.E73Q	DO44299	CESC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.G410R	DO8159	COAD	ICGC	PPTY	ITCH	416:419	Mutation blocking phosphorylation signal	0.6111
p.T72A	DO8642	COAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0556
p.T362P	DO9732	COAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1944
p.M95I	DO9876	COAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1944
p.E382D	DO50403	ESAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation substituting flanking lysine	0.25
p.N251I	DO234336	ESAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1944
p.V374I	DO234405	ESAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.7076
p.R372C	DO222645	ESCA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8301
p.R372C	DO42568	UCEC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8301
p.P416T	DO222677	ESCA	ICGC	PPTY	ITCH	416:419	Mutation altering degron motif	0.7031
p.G369E	DO218443	GACA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.7199
p.P377L	DO228581	GACA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.P377L	DO29708	OV	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.P377L	DO51677	PAAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.P377L	DO42504	UCEC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.P515H	DO218136	GACA	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.P438L	DO233252	GACA	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7582
p.P438L	DO47318	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.7582
p.R93G	DO233641	GACA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.25
p.P336S	DO233791	GACA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1111
p.P329L	DO233870	GACA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.G93R	DO12514	GBM	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.25
p.C87Y	DO10880	GBM	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.7087
p.S323T	DO14157	HNSC	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7116
p.P364L	DO14160	HNSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.25
p.P364L	DO37412	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.25
p.R514I	DO14173	HNSC	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1389
p.A413V	DO228807	LICA	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.25
p.A82S	DO228952	LICA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.7588
p.A77S	DO228976	LICA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1944
p.R93I	DO228986	LICA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.25
p.L97F	DO229029	LICA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation substituting flanking lysine	0.25
p.K267N	DO229031	LICA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.2222
p.V96M	DO229055	LICA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1667
p.P377S	DO50970	LICA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.P377S	DO51254	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.G437S	DO219507	LIHC	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.6993
p.G437S	DO51252	SKCM	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.6993
p.T441N	DO24320	LUAD	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.A262S	DO25434	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7588
p.E94A	DO25471	LUAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.A73S	DO25396	LUAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.K260N	DO24028	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.6918
p.D406H	DO23774	LUAD	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.0556
p.P83H	DO23629	LUAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.7694
p.A413E	DO23608	LUAD	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.25
p.E269K	DO23586	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1667
p.G272R	DO24830	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.0833
p.V337L	DO26132	LUAD	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.0833
p.P367H	DO26042	LUAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.6583
p.P333T	DO26250	LUAD	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1944
p.R372H	DO26596	LUSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8244
p.R372H	DO34432	PACA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8244
p.R372H	DO41871	UCEC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.8244
p.P324A	DO27739	LUSC	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7503
p.A413T	DO26458	LUSC	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.25
p.Q384K	DO26772	LUSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.0833
p.V374L	DO26662	LUSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.6765
p.R495W	DO27310	LUSC	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.R495W	DO41871	UCEC	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.R495L	DO27310	LUSC	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1111
p.G81E	DO27556	LUSC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.3056
p.V426L	DO27532	LUSC	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1111
p.V426L	DO27532	LUSC	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1389
p.Y329C	DO27208	LUSC	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.T425I	DO228338	MALY	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.0833
p.T425I	DO228338	MALY	ICGC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1667
p.T425I	DG-75	haematopoietic and lymphoid tissue	COSMIC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.0833
p.T425I	DG-75	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1667
p.G327R	DO220912	MELA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7568
p.G435D	DO222363	MELA	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation altering degron motif	0.6087
p.G327E	DO222670	MELA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7199
p.G327E	DO38057	SKCM	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7199
p.E94K	DO229127	NKTL	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.S323F	DO218211	ORCA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7982
p.S323F	DO37659	SKCM	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7982
p.V330I	DO33368	PACA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.2778
p.Y80C	DO51493	PACA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2778
p.G81R	DO228673	PRAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.3056
p.P324L	DO51340	PRAD	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7582
p.P324L	BL-41	haematopoietic and lymphoid tissue	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.7582
p.G439E	DO48658	PRAD	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.3056
p.G510R	DO47234	RECA	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.25
p.S265F	DO220087	SARC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation blocking phosphorylation signal	0.7222
p.D263N	DO229446	SKCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.6932
p.D329N	DO229456	SKCA	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.E335K	DO37579	SKCM	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation blocking phosphorylation signal	0.5833
p.S498F	DO37819	SKCM	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1944
p.Y72H	DO37703	SKCM	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0556
p.E74D	DO50291	SKCM	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1111
p.P361S	DO47331	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1667
p.G272E	DO47331	SKCM	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.0833
p.P371S	DO47368	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.6752
p.P262H	DO37941	SKCM	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7694
p.L380S	DO37911	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.1944
p.I88F	DO47631	SKCM	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.6304
p.G93E	DO38153	SKCM	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.25
p.A325V	DO38551	STAD	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.6936
p.A325V	DO42673	UCEC	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation altering degron motif	0.6936
p.P497Q	DO38443	STAD	ICGC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.1667
p.G366W	DO38715	STAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.3056
p.I273T	DO47877	STAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.0556
p.E74V	DO38192	STAD	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1111
p.A73V	DO229213	THCA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.A73V	DO40819	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.A73V	DO41542	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.A73P	DO229240	THCA	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.Q266H	DO42312	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.25
p.P247S	DO223282	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation blocking phosphorylation signal	0.5278
p.S98P	DO223286	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1111
p.G98D	DO43001	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1111
p.G98D	DO43186	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1111
p.G431E	DO43186	UCEC	ICGC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.25
p.F79L	DO52412	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.25
p.R256I	DO41758	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.8102
p.L258M	DO41614	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.711
p.V338M	DO41235	UCEC	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.0556
p.R316Q	DO41235	UCEC	ICGC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation blocking phosphorylation signal	0.5833
p.E87G	DO42745	UCEC	ICGC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.7199
p.G365E	SIDM02026	Colorectal Carcinoma	GDSC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation rewiring degron network	0.2778
p.S430L	SIDM02014	Esophageal Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.2222
p.A501V	SIDM00216	Colorectal Carcinoma	GDSC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.A501V	ACH-000989	Colon/Colorectal Cancer	CCLE	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.A501V	SNU-175	large intestine	COSMIC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.2778
p.W73G	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.W73G	ACH-000226	Lymphoma	CCLE	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.W73G	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.0833
p.K382N	SIDM00845	Burkitt's Lymphoma	GDSC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation substituting flanking lysine	0.25
p.I88M	SIDM00589	Oral Cavity Carcinoma	GDSC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.6507
p.I88M	ACH-000778	Head and Neck Cancer	CCLE	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.6507
p.I88M	HSC-3	upper aerodigestive tract	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.6507
p.A444V	SIDM00596	Endometrial Carcinoma	GDSC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1667
p.A444V	HEC-1	endometrium	COSMIC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1667
p.R408I	SIDM00151	Ovarian Carcinoma	GDSC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1111
p.R408I	ACH-000966	Ovarian Cancer	CCLE	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1111
p.R408I	IGROV-1	ovary	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1111
p.T421I	SIDM00948	Burkitt's Lymphoma	GDSC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.2778
p.T421I	ACH-002232	Lymphoma	CCLE	PPTY	ITCH	416:419	Mutation rewiring degron network	0.2778
p.T421I	DG-75	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.2778
p.P329Q	SIDM00792	Small Cell Lung Carcinoma	GDSC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.P329Q	SIDM01588	Endometrial Carcinoma	GDSC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.P329Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.P329Q	ACH-002170	Lung Cancer	CCLE	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.P329Q	NCI-H1688	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.3056
p.G270V	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1389
p.G270V	ACH-000744	Lung Cancer	CCLE	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1389
p.G270V	NCI-H1623	lung	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.1389
p.V334L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1667
p.V334L	ACH-000852	Lung Cancer	CCLE	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1667
p.V334L	NCI-H1435	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1667
p.R445Q	SIDM01526	Mesothelioma	GDSC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.1389
p.G94S	SIDM00163	Biliary Tract Carcinoma	GDSC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.G94S	ACH-000461	Bile Duct Cancer	CCLE	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.R412I	IGROV-1	ovary	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.2222
p.L258S	PL-21	haematopoietic and lymphoid tissue	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation altering degron motif	0.7667
p.L424I	COR-L321	NS	COSMIC	PGTTS	DEG_SPOP_SBC_1	434:438	Mutation rewiring degron network	0.0556
p.L424I	COR-L321	NS	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1944
p.A368S	BT-20	breast	COSMIC	PRNVLSPLN	DEG_APCC_DBOX_1	367:375	Mutation altering degron motif	0.7588
p.A313V	KATOIII	stomach	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.0556
p.S517N	Mewo	skin	COSMIC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0556
p.S81C	NCI-H1793	lung	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.3056
p.F407C	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.0833
p.D406E	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.0556
p.E74G	LNCaP-Clone-FGC	prostate	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1111
p.P494S	HT-3	cervix	COSMIC	AESTS	DEG_SPOP_SBC_1	503:507	Mutation rewiring degron network	0.0833
p.P264S	HT-3	cervix	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	256:263	Mutation rewiring degron network	0.3056
p.E78G	LNCaP-Clone-FGC	prostate	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2222
p.P409Q	NCI-H1975	lung	COSMIC	PPTY	ITCH	416:419	Mutation rewiring degron network	0.1389
p.V338L	NCI-H1435	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.0556
p.F99C	HCC2998	large intestine	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation substituting flanking lysine	0.1944
p.P333Q	NCI-H1688	lung	COSMIC	VTPELT	DEG_SCF_FBW7_1	323:328	Mutation rewiring degron network	0.1944
p.S83L	HCC2998	large intestine	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation altering degron motif	0.7667
p.I92M	HSC-3	upper aerodigestive tract	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.2778
p.W77G	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	DEEGYSIRP	CBL_PTK	82:90	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGIP1

UniProt ID: Q9BQI5

Entrez ID: 84251

Protein name: SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin-3-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGIP1 in