DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: DEG_SCF_FBW7_1

Location: 256:263

E3 ligase: FBXW7

DEGRON score: 0.9916

ASA_SCORE: 92.7375

COIL: 0.9636

CONS_SCORE: 0.3419

DSS_SCORE: 0.7597

HELIX: 0.0136

FCONS_SCORE: 0.9939

RIG_SCORE: 0.5856

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G270E	TCGA-33-4538	LUSC	TCGA	VPATPPRT	DEG_SCF_FBW7_1	0.1389
p.A258S	TCGA-86-8672	LUAD	TCGA	VPATPPRT	DEG_SCF_FBW7_1	0.6477
p.P271Q	TCGA-91-6836	LUAD	TCGA	VPATPPRT	DEG_SCF_FBW7_1	0.1111
p.P271Q	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VPATPPRT	DEG_SCF_FBW7_1	0.1111
p.P271Q	ACH-000951	Lung Cancer	CCLE	VPATPPRT	DEG_SCF_FBW7_1	0.1111
p.P271Q	NCI-H2342	lung	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	0.1111
p.I269T	TCGA-CD-8531	STAD	TCGA	VPATPPRT	DEG_SCF_FBW7_1	0.1667
p.G270R	TCGA-E5-A4U1	BLCA	TCGA	VPATPPRT	DEG_SCF_FBW7_1	0.1389
p.L267I	TCGA-UY-A78K	BLCA	TCGA	VPATPPRT	DEG_SCF_FBW7_1	0.2222
p.L271I	DO219031	BLCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.1111
p.E253K	DO219024	BLCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.25
p.P262T	DO1707	BRCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.7031
p.P262S	DO2216	BRCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.6752
p.N251I	DO234336	ESAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.1944
p.K267N	DO229031	LICA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.2222
p.A262S	DO25434	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.7588
p.K260N	DO24028	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.6918
p.E269K	DO23586	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.1667
p.G272R	DO24830	LUAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.0833
p.S265F	DO220087	SARC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.7222
p.D263N	DO229446	SKCA	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.6932
p.G272E	DO47331	SKCM	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.0833
p.P262H	DO37941	SKCM	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.7694
p.I273T	DO47877	STAD	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.0556
p.Q266H	DO42312	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.25
p.P247S	DO223282	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.5278
p.R256I	DO41758	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.8102
p.L258M	DO41614	UCEC	ICGC	VPATPPRT	DEG_SCF_FBW7_1	0.711
p.G270V	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	VPATPPRT	DEG_SCF_FBW7_1	0.1389
p.G270V	ACH-000744	Lung Cancer	CCLE	VPATPPRT	DEG_SCF_FBW7_1	0.1389
p.G270V	NCI-H1623	lung	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	0.1389
p.L258S	PL-21	haematopoietic_and_lymphoid_tissue	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	0.7667
p.P264S	HT-3	cervix	COSMIC	VPATPPRT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPATPPRT

Degron related mutations and impact score

Drug responses associated with SGIP1 mutations

All proteins holding degron of VPATPPRT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_SCF_FBW7_1	256:263	VPATPPRT	FBXW7	0.9916	More...