DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: DEG_APCC_DBOX_1

Location: 367:375

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7264

ASA_SCORE: 86.4444

COIL: 0.847

CONS_SCORE: 0.3567

DSS_SCORE: 0.6696

HELIX: 0.1287

FCONS_SCORE: 0.9881

RIG_SCORE: 0.6637

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E385K	TCGA-21-1083	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.0556
p.P373L	TCGA-2L-AAQL	PAAD	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.6471
p.P373L	TCGA-61-2096	OV	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.6471
p.P373L	TCGA-AX-A2HA	UCEC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.6471
p.Q380K	TCGA-34-5231	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.1944
p.V370L	TCGA-43-2578	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.5654
p.R368H	TCGA-43-3394	LUSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.8244
p.R368H	TCGA-B5-A3FC	UCEC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.8244
p.P363H	TCGA-55-5899	LUAD	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.2222
p.R368C	TCGA-A5-A1OF	UCEC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.8301
p.R368C	SIDM00690	Head and Neck Carcinoma	GDSC	PRNVLSPLN	DEG_APCC_DBOX_1	0.8301
p.G359S	TCGA-AG-A002	READ	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.1111
p.G362W	TCGA-BR-4368	STAD	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.1944
p.P360L	TCGA-CV-7568	HNSC	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.1389
p.P360L	TCGA-FS-A1ZZ	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.1389
p.L376S	TCGA-EE-A3AF	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.3056
p.P357S	TCGA-EE-A3J5	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.0556
p.P367S	TCGA-ER-A193	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.5641
p.P373S	TCGA-GF-A6C9	SKCM	TCGA	PRNVLSPLN	DEG_APCC_DBOX_1	0.5641
p.T362P	DO9732	COAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.1944
p.E382D	DO50403	ESAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.25
p.V374I	DO234405	ESAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.7076
p.R372C	DO222645	ESCA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.8301
p.R372C	DO42568	UCEC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.8301
p.G369E	DO218443	GACA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.7199
p.P377L	DO228581	GACA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.P377L	DO29708	OV	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.P377L	DO51677	PAAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.P377L	DO42504	UCEC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.P364L	DO14160	HNSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.25
p.P364L	DO37412	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.25
p.P377S	DO50970	LICA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.P377S	DO51254	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.P367H	DO26042	LUAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.6583
p.R372H	DO26596	LUSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.8244
p.R372H	DO34432	PACA	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.8244
p.R372H	DO41871	UCEC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.8244
p.Q384K	DO26772	LUSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.0833
p.V374L	DO26662	LUSC	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.6765
p.P361S	DO47331	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.1667
p.P371S	DO47368	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.6752
p.L380S	DO37911	SKCM	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.1944
p.G366W	DO38715	STAD	ICGC	PRNVLSPLN	DEG_APCC_DBOX_1	0.3056
p.G365E	SIDM02026	Colorectal Carcinoma	GDSC	PRNVLSPLN	DEG_APCC_DBOX_1	0.2778
p.K382N	SIDM00845	Burkitt's Lymphoma	GDSC	PRNVLSPLN	DEG_APCC_DBOX_1	0.25
p.A368S	BT-20	breast	COSMIC	PRNVLSPLN	DEG_APCC_DBOX_1	0.7588

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRNVLSPLN

Degron related mutations and impact score

Drug responses associated with SGIP1 mutations

All proteins holding degron of PRNVLSPLN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	DEG_APCC_DBOX_1	367:375	PRNVLSPLN	APC,CDC20,FZR1	0.7264	More...