DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: CBL_PTK

Location: 82:90

E3 ligase: CBL

DEGRON score: 0.6914

ASA_SCORE: 61.8889

COIL: 0.6186

CONS_SCORE: 0.3571

DSS_SCORE: 0.6342

HELIX: 0.04

FCONS_SCORE: 1.0186

RIG_SCORE: 0.6871

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P79H	TCGA-64-1676	LUAD	TCGA	DEEGYSIRP	CBL_PTK	0.25
p.G94D	TCGA-AJ-A3OL	UCEC	TCGA	DEEGYSIRP	CBL_PTK	0.2222
p.G94D	TCGA-AP-A1DV	UCEC	TCGA	DEEGYSIRP	CBL_PTK	0.2222
p.E83G	TCGA-BS-A0UJ	UCEC	TCGA	DEEGYSIRP	CBL_PTK	0.6087
p.E83K	TCGA-C8-A8HP	BRCA	TCGA	DEEGYSIRP	CBL_PTK	0.591
p.E87K	DO219621	BRCA	ICGC	DEEGYSIRP	CBL_PTK	0.7022
p.E73Q	DO44299	CESC	ICGC	DEEGYSIRP	CBL_PTK	0.0833
p.T72A	DO8642	COAD	ICGC	DEEGYSIRP	CBL_PTK	0.0556
p.M95I	DO9876	COAD	ICGC	DEEGYSIRP	CBL_PTK	0.1944
p.R93G	DO233641	GACA	ICGC	DEEGYSIRP	CBL_PTK	0.25
p.G93R	DO12514	GBM	ICGC	DEEGYSIRP	CBL_PTK	0.25
p.C87Y	DO10880	GBM	ICGC	DEEGYSIRP	CBL_PTK	0.7087
p.A82S	DO228952	LICA	ICGC	DEEGYSIRP	CBL_PTK	0.7588
p.A77S	DO228976	LICA	ICGC	DEEGYSIRP	CBL_PTK	0.1944
p.R93I	DO228986	LICA	ICGC	DEEGYSIRP	CBL_PTK	0.25
p.L97F	DO229029	LICA	ICGC	DEEGYSIRP	CBL_PTK	0.25
p.V96M	DO229055	LICA	ICGC	DEEGYSIRP	CBL_PTK	0.1667
p.E94A	DO25471	LUAD	ICGC	DEEGYSIRP	CBL_PTK	0.2222
p.A73S	DO25396	LUAD	ICGC	DEEGYSIRP	CBL_PTK	0.0833
p.P83H	DO23629	LUAD	ICGC	DEEGYSIRP	CBL_PTK	0.7694
p.G81E	DO27556	LUSC	ICGC	DEEGYSIRP	CBL_PTK	0.3056
p.E94K	DO229127	NKTL	ICGC	DEEGYSIRP	CBL_PTK	0.2222
p.Y80C	DO51493	PACA	ICGC	DEEGYSIRP	CBL_PTK	0.2778
p.G81R	DO228673	PRAD	ICGC	DEEGYSIRP	CBL_PTK	0.3056
p.Y72H	DO37703	SKCM	ICGC	DEEGYSIRP	CBL_PTK	0.0556
p.E74D	DO50291	SKCM	ICGC	DEEGYSIRP	CBL_PTK	0.1111
p.I88F	DO47631	SKCM	ICGC	DEEGYSIRP	CBL_PTK	0.6304
p.G93E	DO38153	SKCM	ICGC	DEEGYSIRP	CBL_PTK	0.25
p.E74V	DO38192	STAD	ICGC	DEEGYSIRP	CBL_PTK	0.1111
p.A73V	DO229213	THCA	ICGC	DEEGYSIRP	CBL_PTK	0.0833
p.A73V	DO40819	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.0833
p.A73V	DO41542	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.0833
p.A73P	DO229240	THCA	ICGC	DEEGYSIRP	CBL_PTK	0.0833
p.S98P	DO223286	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.1111
p.G98D	DO43001	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.1111
p.G98D	DO43186	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.1111
p.F79L	DO52412	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.25
p.E87G	DO42745	UCEC	ICGC	DEEGYSIRP	CBL_PTK	0.7199
p.W73G	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	DEEGYSIRP	CBL_PTK	0.0833
p.W73G	ACH-000226	Lymphoma	CCLE	DEEGYSIRP	CBL_PTK	0.0833
p.W73G	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	DEEGYSIRP	CBL_PTK	0.0833
p.I88M	SIDM00589	Oral Cavity Carcinoma	GDSC	DEEGYSIRP	CBL_PTK	0.6507
p.I88M	ACH-000778	Head and Neck Cancer	CCLE	DEEGYSIRP	CBL_PTK	0.6507
p.I88M	HSC-3	upper_aerodigestive_tract	COSMIC	DEEGYSIRP	CBL_PTK	0.6507
p.G94S	SIDM00163	Biliary Tract Carcinoma	GDSC	DEEGYSIRP	CBL_PTK	0.2222
p.G94S	ACH-000461	Bile Duct Cancer	CCLE	DEEGYSIRP	CBL_PTK	0.2222
p.S81C	NCI-H1793	lung	COSMIC	DEEGYSIRP	CBL_PTK	0.3056
p.E74G	LNCaP-Clone-FGC	prostate	COSMIC	DEEGYSIRP	CBL_PTK	0.1111
p.E78G	LNCaP-Clone-FGC	prostate	COSMIC	DEEGYSIRP	CBL_PTK	0.2222
p.F99C	HCC2998	large_intestine	COSMIC	DEEGYSIRP	CBL_PTK	0.1944
p.S83L	HCC2998	large_intestine	COSMIC	DEEGYSIRP	CBL_PTK	0.7667
p.I92M	HSC-3	upper_aerodigestive_tract	COSMIC	DEEGYSIRP	CBL_PTK	0.2778
p.W77G	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	DEEGYSIRP	CBL_PTK	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DEEGYSIRP

Degron related mutations and impact score

Drug responses associated with SGIP1 mutations

All proteins holding degron of DEEGYSIRP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	CBL_PTK	82:90	DEEGYSIRP	CBL	0.6914	More...