DegronMD

Uniprot ID: Q9BQI5

Source protein: SH3-containing GRB2-like protein 3-interacting protein 1

Source gene: SGIP1

Class: ITCH

Location: 416:419

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9553

ASA_SCORE: 94.45

COIL: 0.651

CONS_SCORE: 0.3728

DSS_SCORE: 0.7909

HELIX: 0.3405

FCONS_SCORE: 1.0806

RIG_SCORE: 0.5953

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V422L	TCGA-39-5011	LUSC	TCGA	PPTY	ITCH	0.25
p.A409T	TCGA-77-8148	LUSC	TCGA	PPTY	ITCH	0.1389
p.A409E	TCGA-91-6840	LUAD	TCGA	PPTY	ITCH	0.1389
p.P414L	TCGA-AC-A5XS	BRCA	TCGA	PPTY	ITCH	0.2778
p.G427E	TCGA-AP-A1DV	UCEC	TCGA	PPTY	ITCH	0.1111
p.R408S	TCGA-FJ-A3ZE	BLCA	TCGA	PPTY	ITCH	0.1111
p.S424L	TCGA-FS-A4FC	SKCM	TCGA	PPTY	ITCH	0.1944
p.G406R	TCGA-G4-6320	COAD	TCGA	PPTY	ITCH	0.0556
p.R412S	DO484	BLCA	ICGC	PPTY	ITCH	0.2222
p.S428L	DO228452	BRCA	ICGC	PPTY	ITCH	0.0833
p.S428L	DO37762	SKCM	ICGC	PPTY	ITCH	0.0833
p.P418L	DO50023	BRCA	ICGC	PPTY	ITCH	0.7582
p.G410R	DO8159	COAD	ICGC	PPTY	ITCH	0.6111
p.P416T	DO222677	ESCA	ICGC	PPTY	ITCH	0.7031
p.A413V	DO228807	LICA	ICGC	PPTY	ITCH	0.25
p.D406H	DO23774	LUAD	ICGC	PPTY	ITCH	0.0556
p.A413E	DO23608	LUAD	ICGC	PPTY	ITCH	0.25
p.A413T	DO26458	LUSC	ICGC	PPTY	ITCH	0.25
p.V426L	DO27532	LUSC	ICGC	PPTY	ITCH	0.1389
p.T425I	DO228338	MALY	ICGC	PPTY	ITCH	0.1667
p.T425I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PPTY	ITCH	0.1667
p.R408I	SIDM00151	Ovarian Carcinoma	GDSC	PPTY	ITCH	0.1111
p.R408I	ACH-000966	Ovarian Cancer	CCLE	PPTY	ITCH	0.1111
p.R408I	IGROV-1	ovary	COSMIC	PPTY	ITCH	0.1111
p.T421I	SIDM00948	Burkitt's Lymphoma	GDSC	PPTY	ITCH	0.2778
p.T421I	ACH-002232	Lymphoma	CCLE	PPTY	ITCH	0.2778
p.T421I	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PPTY	ITCH	0.2778
p.R412I	IGROV-1	ovary	COSMIC	PPTY	ITCH	0.2222
p.L424I	COR-L321	NS	COSMIC	PPTY	ITCH	0.1944
p.F407C	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPTY	ITCH	0.0833
p.D406E	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PPTY	ITCH	0.0556
p.P409Q	NCI-H1975	lung	COSMIC	PPTY	ITCH	0.1389

Drug responses associated with SGIP1 mutations

All proteins holding degron of PPTY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	ITCH	3280:3283	PPTY	ITCH,NEDD4	0.9968	More...
O14514	Adhesion G protein-coupled receptor B1	ITCH	628:631	PPTY	ITCH,NEDD4	0.9223	More...
O14578	Citron Rho-interacting kinase	ITCH	1926:1929	PPTY	ITCH,NEDD4	0.5412	More...
O14686	Histone-lysine N-methyltransferase 2D	ITCH	2193:2196	PPTY	ITCH,NEDD4	0.9967	More...
O15165	Low-density lipoprotein receptor class A domain-containing protein 4	ITCH	252:255	PPTY	ITCH,NEDD4	0.9918	More...
O15357	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2	ITCH	658:661	PPTY	ITCH,NEDD4	0.6551	More...
O75175	CCR4-NOT transcription complex subunit 3	ITCH	320:323	PPTY	ITCH,NEDD4	0.7287	More...
O75909	Cyclin-K	ITCH	510:513	PPTY	ITCH,NEDD4	0.7979	More...
P21796	Voltage-dependent anion-selective channel protein 1	ITCH	4:7	PPTY	ITCH,NEDD4	0.5246	More...
P23759	Paired box protein Pax-7	ITCH	444:447	PPTY	ITCH,NEDD4	0.9893	More...
P23760	Paired box protein Pax-3	ITCH	450:453	PPTY	ITCH,NEDD4	0.9541	More...
P25391	Laminin subunit alpha-1	ITCH	171:174	PPTY	ITCH,NEDD4	0.9366	More...
P82650	28S ribosomal protein S22, mitochondrial	ITCH	100:103	PPTY	ITCH,NEDD4	0.9899	More...
Q00341	Vigilin	ITCH	37:40	PPTY	ITCH,NEDD4	0.6855	More...
Q01892	Transcription factor Spi-B	ITCH	80:83	PPTY	ITCH,NEDD4	0.9975	More...
Q12824	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1	ITCH	116:119	PPTY	ITCH,NEDD4	0.9984	More...
Q13459	Unconventional myosin-IXb	ITCH	2143:2146	PPTY	ITCH,NEDD4	0.9285	More...
Q68CP9	AT-rich interactive domain-containing protein 2	ITCH	1581:1584	PPTY	ITCH,NEDD4	0.9943	More...
Q7Z478	ATP-dependent RNA helicase DHX29	ITCH	459:462	PPTY	ITCH,NEDD4	0.8751	More...
Q86U70	LIM domain-binding protein 1	ITCH	49:52	PPTY	ITCH,NEDD4	0.9966	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	ITCH	41:44	PPTY	ITCH,NEDD4	0.9955	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	ITCH	666:669	PPTY	ITCH,NEDD4	0.8045	More...
Q92859	Neogenin	ITCH	1372:1375	PPTY	ITCH,NEDD4	0.9601	More...
Q93050	V-type proton ATPase 116 kDa subunit a 1	ITCH	361:364	PPTY	ITCH,NEDD4	0.9108	More...
Q969W9	Protein TMEPAI	ITCH	229:232	PPTY	ITCH,NEDD4	0.9995	More...
Q9BQI5	SH3-containing GRB2-like protein 3-interacting protein 1	ITCH	416:419	PPTY	ITCH,NEDD4	0.9553	More...
Q9BRG2	SH2 domain-containing protein 3A	ITCH	228:231	PPTY	ITCH,NEDD4	0.9875	More...
Q9BSA4	Protein tweety homolog 2	ITCH	506:509	PPTY	ITCH,NEDD4	0.9004	More...
Q9BT40	Inositol polyphosphate 5-phosphatase K	ITCH	244:247	PPTY	ITCH,NEDD4	0.9245	More...
Q9H3M7	Thioredoxin-interacting protein	ITCH	375:378	PPTY	ITCH,NEDD4	0.9994	More...
Q9H6T0	Epithelial splicing regulatory protein 2	ITCH	584:587	PPTY	ITCH,NEDD4	0.9502	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4182:4185	PPTY	ITCH,NEDD4	0.9282	More...
Q9P2K8	eIF-2-alpha kinase GCN2	ITCH	80:83	PPTY	ITCH,NEDD4	0.7591	More...
Q9UJQ4	Sal-like protein 4	ITCH	833:836	PPTY	ITCH,NEDD4	0.9797	More...
Q9UPA5	Protein bassoon	ITCH	1952:1955	PPTY	ITCH,NEDD4	0.8543	More...
Q9Y6I3	Epsin-1	ITCH	545:548	PPTY	ITCH,NEDD4	0.7626	More...
O14668	Transmembrane gamma-carboxyglutamic acid protein 1	ITCH	169:172	PPTY	ITCH,NEDD4	0.998	More...
Q5JSZ5	Protein PRRC2B	ITCH	275:278	PPTY	ITCH,NEDD4	0.8146	More...
Q9UKU9	Angiopoietin-related protein 2	ITCH	227:230	PPTY	ITCH,NEDD4	0.7151	More...
Q96K62	Zinc finger and BTB domain-containing protein 45	ITCH	400:403	PPTY	ITCH,NEDD4	0.7412	More...
A6NMK8	Protein INSYN2B	ITCH	76:79	PPTY	ITCH,NEDD4	0.8124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTY

Degron related mutations and impact score

Drug responses associated with SGIP1 mutations

All proteins holding degron of PPTY