DegronMD - Q9NYQ8(FAT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2269T	TCGA-06-0169	GBM	TCGA	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.1389
p.P2269T	DO13102	GBM	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.1389
p.S4334F	TCGA-4T-AA8H	COAD	TCGA	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.S4334F	DO51724	COAD	ICGC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.Q2288E	TCGA-4Z-AA80	BLCA	TCGA	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.1111
p.Q2288E	DO218986	BLCA	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.1111
p.P4238R	TCGA-56-5898	LUSC	TCGA	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.2778
p.P4238R	DO26548	LUSC	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.2778
p.S4186Y	TCGA-78-7152	LUAD	TCGA	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.3056
p.S4186Y	DO23560	LUAD	ICGC	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.3056
p.M4232L	TCGA-AA-3811	COAD	TCGA	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1111
p.M4232L	DO7962	COAD	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1111
p.M4232L	SIDM00845	Burkitt's Lymphoma	GDSC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1111
p.M4252I	TCGA-AG-A002	READ	TCGA	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.0833
p.G4177R	TCGA-AP-A1DV	UCEC	TCGA	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.1944
p.G4177R	DO43186	UCEC	ICGC	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.1944
p.G4177R	SIDM00238	Ovarian Carcinoma	GDSC	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.1944
p.G4177R	ACH-000947	Ovarian Cancer	CCLE	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.1944
p.G4177R	OVK-18	ovary	COSMIC	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.1944
p.T2278A	TCGA-AX-A05Z	UCEC	TCGA	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation altering degron motif	0.7139
p.T2278A	DO40884	UCEC	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation altering degron motif	0.7139
p.D2338N	TCGA-AX-A0J1	UCEC	TCGA	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.1111
p.D2338N	DO41199	UCEC	ICGC	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.1111
p.S2316P	TCGA-AX-A2HJ	UCEC	TCGA	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.0833
p.S2316P	DO42105	UCEC	ICGC	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.0833
p.D4250N	TCGA-BF-AAP4	SKCM	TCGA	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1389
p.D4250N	DO219468	SKCM	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1389
p.E2340V	TCGA-CM-5868	COAD	TCGA	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.0556
p.E2340V	DO7894	COAD	ICGC	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.0556
p.P4325S	TCGA-CV-6954	HNSC	TCGA	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.P4325S	DO15959	HNSC	ICGC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.Q2274K	TCGA-D3-A2JG	SKCM	TCGA	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.Q2274K	DO47613	SKCM	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.D4250Y	TCGA-DF-A2KU	UCEC	TCGA	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1389
p.D4250Y	DO223286	UCEC	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1389
p.M4336T	TCGA-DX-A6YV	SARC	TCGA	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.1944
p.M4336T	DO220011	SARC	ICGC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.1944
p.Q2274R	TCGA-EE-A2A5	SKCM	TCGA	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.Q2274R	DO37941	SKCM	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.S2332P	TCGA-F5-6814	READ	TCGA	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.2778
p.S2332P	DO36556	READ	ICGC	NGSTGE	DEG_Kelch_Keap1_1	2325:2330	Mutation rewiring degron network	0.2778
p.T2289A	TCGA-F7-A624	HNSC	TCGA	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.0833
p.T2289A	DO44440	HNSC	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.0833
p.R4326Q	TCGA-G4-6628	COAD	TCGA	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.2778
p.R4326Q	DO10132	COAD	ICGC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.2778
p.H4195Y	TCGA-HR-A2OH	SKCM	TCGA	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.0556
p.H4195Y	DO37774	SKCM	ICGC	PPTY	ITCH	4182:4185	Mutation rewiring degron network	0.0556
p.T4184A	TCGA-L5-A8NM	ESCA	TCGA	PPTY	ITCH	4182:4185	Mutation altering degron motif	0.6028
p.R4242H	TCGA-WS-AB45	COAD	TCGA	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.7133
p.R4242H	DO51734	COAD	ICGC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.7133
p.R4242H	SIDM00773	Non-Cancerous	GDSC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.7133
p.R4236Q	DO222992	BTCA	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.2222
p.R4242C	DO234215	ESAD	ICGC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.719
p.A4320E	DO234437	ESAD	ICGC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.1111
p.A4237E	DO229027	LICA	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.25
p.N4234K	DO229032	LICA	ICGC	PPRY	ITCH	4240:4243	Mutation rewiring degron network	0.1667
p.Q2288K	DO222363	MELA	ICGC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.1111
p.R4242L	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.7316
p.R4242L	ACH-001233	Lung Cancer	CCLE	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.7316
p.R4242L	VMRC-LCD	lung	COSMIC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.7316
p.E4332D	SIDM00794	Other Solid Cancers	GDSC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.3056
p.E4332D	ACH-001442	Skin Cancer	CCLE	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.3056
p.E4332D	A388	skin	COSMIC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.3056
p.R4242S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.6316
p.R4242S	ACH-000900	Lung Cancer	CCLE	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.6316
p.R4242S	NCI-H23	lung	COSMIC	PPRY	ITCH	4240:4243	Mutation altering degron motif	0.6316
p.S2282L	SIDM00560	Gastric Carcinoma	GDSC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.S2282L	ACH-000678	Gastric Cancer	CCLE	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.S2282L	MKN7	stomach	COSMIC	VYTTS	DEG_SPOP_SBC_1	2276:2280	Mutation rewiring degron network	0.2778
p.P4325L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.P4325L	ACH-000916	Lung Cancer	CCLE	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.P4325L	NCI-H1573	lung	COSMIC	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.25
p.P4318L	ACH-001521	Skin Cancer	CCLE	PPNY	ITCH	4328:4331	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAT2

UniProt ID: Q9NYQ8

Entrez ID: 2196

Protein name: Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAT2 in