DegronMD

Uniprot ID: Q9NYQ8

Source protein: Protocadherin Fat 2

Source gene: FAT2

Class: DEG_SPOP_SBC_1

Location: 2276:2280

E3 ligase: SPOP

DEGRON score: 0.9142

ASA_SCORE: 51.32

COIL: 0.0802

CONS_SCORE: 0.5605

DSS_SCORE: 0.4036

HELIX: 0.0024

FCONS_SCORE: 0.8818

RIG_SCORE: 0.8459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2269T	TCGA-06-0169	GBM	TCGA	VYTTS	DEG_SPOP_SBC_1	0.1389
p.P2269T	DO13102	GBM	ICGC	VYTTS	DEG_SPOP_SBC_1	0.1389
p.Q2288E	TCGA-4Z-AA80	BLCA	TCGA	VYTTS	DEG_SPOP_SBC_1	0.1111
p.Q2288E	DO218986	BLCA	ICGC	VYTTS	DEG_SPOP_SBC_1	0.1111
p.T2278A	TCGA-AX-A05Z	UCEC	TCGA	VYTTS	DEG_SPOP_SBC_1	0.7139
p.T2278A	DO40884	UCEC	ICGC	VYTTS	DEG_SPOP_SBC_1	0.7139
p.Q2274K	TCGA-D3-A2JG	SKCM	TCGA	VYTTS	DEG_SPOP_SBC_1	0.2778
p.Q2274K	DO47613	SKCM	ICGC	VYTTS	DEG_SPOP_SBC_1	0.2778
p.Q2274R	TCGA-EE-A2A5	SKCM	TCGA	VYTTS	DEG_SPOP_SBC_1	0.2778
p.Q2274R	DO37941	SKCM	ICGC	VYTTS	DEG_SPOP_SBC_1	0.2778
p.T2289A	TCGA-F7-A624	HNSC	TCGA	VYTTS	DEG_SPOP_SBC_1	0.0833
p.T2289A	DO44440	HNSC	ICGC	VYTTS	DEG_SPOP_SBC_1	0.0833
p.Q2288K	DO222363	MELA	ICGC	VYTTS	DEG_SPOP_SBC_1	0.1111
p.S2282L	SIDM00560	Gastric Carcinoma	GDSC	VYTTS	DEG_SPOP_SBC_1	0.2778
p.S2282L	ACH-000678	Gastric Cancer	CCLE	VYTTS	DEG_SPOP_SBC_1	0.2778
p.S2282L	MKN7	stomach	COSMIC	VYTTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYQ8	Protocadherin Fat 2	DEG_SPOP_SBC_1	2276:2280	VYTTS	SPOP	0.9142	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons