DegronMD

Uniprot ID: Q9NYQ8

Source protein: Protocadherin Fat 2

Source gene: FAT2

Class: ITCH

Location: 4240:4243

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9922

ASA_SCORE: 79.425

COIL: 0.925

CONS_SCORE: 0.4375

DSS_SCORE: 0.5696

HELIX: 0.0385

FCONS_SCORE: 0.9548

RIG_SCORE: 0.6591

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P4238R	TCGA-56-5898	LUSC	TCGA	PPRY	ITCH	0.2778
p.P4238R	DO26548	LUSC	ICGC	PPRY	ITCH	0.2778
p.M4232L	TCGA-AA-3811	COAD	TCGA	PPRY	ITCH	0.1111
p.M4232L	DO7962	COAD	ICGC	PPRY	ITCH	0.1111
p.M4232L	SIDM00845	Burkitt's Lymphoma	GDSC	PPRY	ITCH	0.1111
p.M4252I	TCGA-AG-A002	READ	TCGA	PPRY	ITCH	0.0833
p.D4250N	TCGA-BF-AAP4	SKCM	TCGA	PPRY	ITCH	0.1389
p.D4250N	DO219468	SKCM	ICGC	PPRY	ITCH	0.1389
p.D4250Y	TCGA-DF-A2KU	UCEC	TCGA	PPRY	ITCH	0.1389
p.D4250Y	DO223286	UCEC	ICGC	PPRY	ITCH	0.1389
p.R4242H	TCGA-WS-AB45	COAD	TCGA	PPRY	ITCH	0.7133
p.R4242H	DO51734	COAD	ICGC	PPRY	ITCH	0.7133
p.R4242H	SIDM00773	Non-Cancerous	GDSC	PPRY	ITCH	0.7133
p.R4236Q	DO222992	BTCA	ICGC	PPRY	ITCH	0.2222
p.R4242C	DO234215	ESAD	ICGC	PPRY	ITCH	0.719
p.A4237E	DO229027	LICA	ICGC	PPRY	ITCH	0.25
p.N4234K	DO229032	LICA	ICGC	PPRY	ITCH	0.1667
p.R4242L	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	PPRY	ITCH	0.7316
p.R4242L	ACH-001233	Lung Cancer	CCLE	PPRY	ITCH	0.7316
p.R4242L	VMRC-LCD	lung	COSMIC	PPRY	ITCH	0.7316
p.R4242S	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PPRY	ITCH	0.6316
p.R4242S	ACH-000900	Lung Cancer	CCLE	PPRY	ITCH	0.6316
p.R4242S	NCI-H23	lung	COSMIC	PPRY	ITCH	0.6316

Drug responses associated with FAT2 mutations

All proteins holding degron of PPRY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	ITCH	717:720	PPRY	ITCH,NEDD4	0.7033	More...
O00299	Chloride intracellular channel protein 1	ITCH	90:93	PPRY	ITCH,NEDD4	0.8886	More...
O15247	Chloride intracellular channel protein 2	ITCH	96:99	PPRY	ITCH,NEDD4	0.9319	More...
O43313	ATM interactor	ITCH	287:290	PPRY	ITCH,NEDD4	0.9841	More...
O43435	T-box transcription factor TBX1	ITCH	47:50	PPRY	ITCH,NEDD4	0.9424	More...
O75208	Ubiquinone biosynthesis protein COQ9, mitochondrial	ITCH	79:82	PPRY	ITCH,NEDD4	0.8635	More...
O95793	Double-stranded RNA-binding protein Staufen homolog 1	ITCH	113:116	PPRY	ITCH,NEDD4	0.9455	More...
P05198	Eukaryotic translation initiation factor 2 subunit 1	ITCH	232:235	PPRY	ITCH,NEDD4	0.6815	More...
P21860	Receptor tyrosine-protein kinase erbB-3	ITCH	972:975	PPRY	ITCH,NEDD4	0.9993	More...
P30876	DNA-directed RNA polymerase II subunit RPB2	ITCH	81:84	PPRY	ITCH,NEDD4	0.9176	More...
P53007	Tricarboxylate transport protein, mitochondrial	ITCH	61:64	PPRY	ITCH,NEDD4	0.7489	More...
P54753	Ephrin type-B receptor 3	ITCH	438:441	PPRY	ITCH,NEDD4	0.969	More...
Q09327	Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	ITCH	148:151	PPRY	ITCH,NEDD4	0.9144	More...
Q13825	Methylglutaconyl-CoA hydratase, mitochondrial	ITCH	333:336	PPRY	ITCH,NEDD4	0.5278	More...
Q14332	Frizzled-2	ITCH	189:192	PPRY	ITCH,NEDD4	0.5291	More...
Q14526	Hypermethylated in cancer 1 protein	ITCH	377:380	PPRY	ITCH,NEDD4	0.9217	More...
Q5CZC0	Fibrous sheath-interacting protein 2	ITCH	5867:5870	PPRY	ITCH,NEDD4	0.994	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	ITCH	1458:1461	PPRY	ITCH,NEDD4	0.5362	More...
Q6VAB6	Kinase suppressor of Ras 2	ITCH	486:489	PPRY	ITCH,NEDD4	0.9326	More...
Q86TB9	Protein PAT1 homolog 1	ITCH	221:224	PPRY	ITCH,NEDD4	0.9488	More...
Q8TC29	Enkurin	ITCH	24:27	PPRY	ITCH,NEDD4	0.9988	More...
Q8WUF5	RelA-associated inhibitor	ITCH	67:70	PPRY	ITCH,NEDD4	0.994	More...
Q8WWW0	Ras association domain-containing protein 5	ITCH	21:24	PPRY	ITCH,NEDD4	0.8918	More...
Q96NY7	Chloride intracellular channel protein 6	ITCH	553:556	PPRY	ITCH,NEDD4	0.9782	More...
Q96SN8	CDK5 regulatory subunit-associated protein 2	ITCH	1239:1242	PPRY	ITCH,NEDD4	0.9754	More...
Q96T58	Msx2-interacting protein	ITCH	771:774	PPRY	ITCH,NEDD4	0.7541	More...
Q99959	Plakophilin-2	ITCH	191:194	PPRY	ITCH,NEDD4	0.9964	More...
Q9H2D6	TRIO and F-actin-binding protein	ITCH	1029:1032	PPRY	ITCH,NEDD4	0.9563	More...
Q9NQL9	Doublesex- and mab-3-related transcription factor 3	ITCH	365:368	PPRY	ITCH,NEDD4	0.9917	More...
Q9NR12	PDZ and LIM domain protein 7	ITCH	101:104	PPRY	ITCH,NEDD4	0.9771	More...
Q9NU39	Forkhead box protein D4-like 1	ITCH	266:269	PPRY	ITCH,NEDD4	0.9298	More...
Q9NYQ8	Protocadherin Fat 2	ITCH	4240:4243	PPRY	ITCH,NEDD4	0.9922	More...
Q9UJV9	Probable ATP-dependent RNA helicase DDX41	ITCH	148:151	PPRY	ITCH,NEDD4	0.9995	More...
Q9ULH7	Myocardin-related transcription factor B	ITCH	871:874	PPRY	ITCH,NEDD4	0.999	More...
O15417	Trinucleotide repeat-containing gene 18 protein	ITCH	1079:1082	PPRY	ITCH,NEDD4	0.9345	More...
Q8WVE6	Transmembrane protein 171	ITCH	301:304	PPRY	ITCH,NEDD4	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPRY

Degron related mutations and impact score

Drug responses associated with FAT2 mutations

All proteins holding degron of PPRY