DegronMD - Q5CZC0(FSIP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V5879I	TCGA-09-2043	OV	TCGA	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.0833
p.K5724N	TCGA-44-2662	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.0556
p.L6377V	TCGA-AA-A00N	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.0556
p.L6377V	DO9876	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.0556
p.E5446G	TCGA-AX-A1CE	UCEC	TCGA	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.1111
p.E5446G	DO42280	UCEC	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.1111
p.D6362Y	TCGA-B5-A0JY	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.3056
p.D6362Y	DO43041	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.3056
p.D5748N	TCGA-BF-AAP4	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.0556
p.D5748N	DO229446	SKCA	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.0556
p.D5748N	DO219468	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.0556
p.D6362G	TCGA-BR-8680	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.3056
p.D6362G	DO47769	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.3056
p.M5547V	TCGA-BS-A0UF	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation rewiring degron network	0.2222
p.M5547V	DO41488	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation rewiring degron network	0.2222
p.E5744K	TCGA-BT-A20J	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1667
p.E5744K	DO457	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1667
p.D5438N	TCGA-CN-6013	HNSC	TCGA	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation altering degron motif	0.6932
p.S5441F	TCGA-CN-6013	HNSC	TCGA	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.25
p.S5441F	DO15975	HNSC	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.25
p.D5859N	TCGA-D3-A8GC	SKCM	TCGA	PPRY	ITCH	5867:5870	Mutation substituting flanking lysine	0.2222
p.D5859N	TCGA-D3-A8GL	SKCM	TCGA	PPRY	ITCH	5867:5870	Mutation substituting flanking lysine	0.2222
p.D5859N	DO50287	SKCM	ICGC	PPRY	ITCH	5867:5870	Mutation substituting flanking lysine	0.2222
p.D5859N	DO50281	SKCM	ICGC	PPRY	ITCH	5867:5870	Mutation substituting flanking lysine	0.2222
p.R5739G	TCGA-D6-A4ZB	HNSC	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.3056
p.R5739G	DO44446	HNSC	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.3056
p.A5873T	TCGA-DD-AAVP	LIHC	TCGA	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.A5873T	TCGA-DX-A3UA	SARC	TCGA	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.A5873T	DO52275	LIHC	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.A5873T	DO219977	SARC	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5739Q	TCGA-DK-A6AW	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.3056
p.R5739Q	TCGA-EE-A3JD	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.3056
p.R5739Q	DO48566	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.3056
p.R5739Q	DO50299	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.3056
p.E5865D	TCGA-DK-A6AW	BLCA	TCGA	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.L5727I	TCGA-DK-AA6R	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1389
p.L5727I	TCGA-EY-A215	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1389
p.L5727I	TCGA-GR-A4D9	DLBC	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1389
p.I5553M	TCGA-EO-A22X	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation rewiring degron network	0.0556
p.T5731A	TCGA-EO-A3AV	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.25
p.T5731A	DO52412	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.25
p.N5743I	TCGA-HU-8249	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1944
p.K5874R	TCGA-HU-A4G8	STAD	TCGA	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2222
p.K5874R	DO47819	STAD	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2222
p.E5436K	DO219006	BLCA	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation altering degron motif	0.7022
p.L5439I	DO225325	BRCA	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.3056
p.N3931D	DO227999	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.N3931D	DO229010	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.N3931D	DO229013	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.N3931D	DO229016	COCA	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.N3931D	DO234285	ESAD	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.N3931D	DO229047	LICA	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.N3931D	DO231212	LUSC	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1944
p.R5864Q	DO227999	COCA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5864Q	DO229010	COCA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5864Q	DO229013	COCA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5864Q	DO229016	COCA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5864Q	DO234204	ESAD	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5864Q	DO234285	ESAD	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.R5864Q	DO229047	LICA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.25
p.S6371F	DO224721	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation substituting flanking lysine	0.3333
p.D5878N	DO222762	COCA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.1111
p.E4130D	DO222798	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	4128:4132	Mutation altering degron motif	0.6758
p.P4128S	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	4128:4132	Mutation altering degron motif	0.6752
p.E5872K	DO229013	COCA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.T3930I	DO50393	ESAD	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1667
p.T5542N	DO234372	ESAD	ICGC	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation altering degron motif	0.7055
p.S5428A	DO48211	ESCA	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.1667
p.D6369N	DO223002	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.2778
p.S5737L	DO219080	HNSC	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation altering degron motif	0.7667
p.S5547R	DO232014	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation rewiring degron network	0.2222
p.S6364I	DO229022	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation altering degron motif	0.623
p.S6364I	DO229037	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation altering degron motif	0.623
p.E5744D	DO229036	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1667
p.E5534D	DO229035	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation rewiring degron network	0.1944
p.P5872S	DO220877	MELA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.P5872S	DO220908	MELA	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.D5448N	DO220876	MELA	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.0556
p.D5448N	DO222363	MELA	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.0556
p.E6370K	DO222363	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.25
p.A6353V	DO33800	PACA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation rewiring degron network	0.0556
p.P5867H	DO232224	PBCA	ICGC	PPRY	ITCH	5867:5870	Mutation altering degron motif	0.7694
p.E5735K	DO229453	SKCA	ICGC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation altering degron motif	0.7022
p.T5543I	DO37583	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation altering degron motif	0.7078
p.E5877K	DO47374	SKCM	ICGC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.1389
p.S6367R	DO229257	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	6363:6367	Mutation altering degron motif	0.8538
p.V3941M	DO42673	UCEC	ICGC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.3056
p.E5436D	DO41379	UCEC	ICGC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation altering degron motif	0.6758
p.S5728P	SIDM00262	Ewing's Sarcoma	GDSC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1667
p.S5728P	ACH-002107	Bone Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1667
p.S5728P	ES6	bone	COSMIC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation rewiring degron network	0.1667
p.T5738A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation altering degron motif	0.7139
p.T5738A	ACH-002256	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation altering degron motif	0.7139
p.T5738A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation altering degron motif	0.7139
p.D4133N	SIDM00140	Melanoma	GDSC	PRSSS	DEG_SPOP_SBC_1	4128:4132	Mutation rewiring degron network	0.3056
p.D4133N	COLO-792	skin	COSMIC	PRSSS	DEG_SPOP_SBC_1	4128:4132	Mutation rewiring degron network	0.3056
p.K5733I	SIDM00539	Esophageal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation blocking ubiquitination signal	0.75
p.K5733I	SIDM00954	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation blocking ubiquitination signal	0.75
p.K5733I	SIDM01140	Ovarian Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	5734:5738	Mutation blocking ubiquitination signal	0.75
p.A3928S	SIDM00534	Colorectal Carcinoma	GDSC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1111
p.A3928S	ACH-000986	Colon/Colorectal Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1111
p.A3928S	HT-115	large intestine	COSMIC	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation rewiring degron network	0.1111
p.E5872G	SIDM00850	Gastric Carcinoma	GDSC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.E5872G	ACH-000880	Gastric Cancer	CCLE	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.E5872G	AGS	stomach	COSMIC	PPRY	ITCH	5867:5870	Mutation rewiring degron network	0.2778
p.D5443Y	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.1944
p.D5443Y	ACH-000888	Lung Cancer	CCLE	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.1944
p.D5443Y	NCI-H1793	lung	COSMIC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.1944
p.S5440Y	SIDM01588	Endometrial Carcinoma	GDSC	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.2778
p.S5440Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	AKENQ	DEG_APCC_KENBOX_2	5434:5438	Mutation rewiring degron network	0.2778
p.K3932R	ACH-001956	Bone Cancer	CCLE	VKSSS	DEG_SPOP_SBC_1	3936:3940	Mutation substituting flanking lysine	0.3333
p.T5550S	ACH-001992	Primary	CCLE	VTSTT	DEG_SPOP_SBC_1	5539:5543	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FSIP2

UniProt ID: Q5CZC0

Entrez ID: 401024

Protein name: Fibrous sheath-interacting protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FSIP2 in