DegronMD

Uniprot ID: Q5CZC0

Source protein: Fibrous sheath-interacting protein 2

Source gene: FSIP2

Class: DEG_SPOP_SBC_1

Location: 5539:5543

E3 ligase: SPOP

DEGRON score: 0.9748

ASA_SCORE: 71.24

COIL: 0.5196

CONS_SCORE: 0.3294

DSS_SCORE: 0.5625

HELIX: 0.0242

FCONS_SCORE: 0.8302

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M5547V	TCGA-BS-A0UF	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.2222
p.M5547V	DO41488	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2222
p.I5553M	TCGA-EO-A22X	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0556
p.T5542N	DO234372	ESAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7055
p.S5547R	DO232014	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2222
p.E5534D	DO229035	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1944
p.T5543I	DO37583	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7078
p.T5550S	ACH-001992	Primary	CCLE	VTSTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons