DegronMD

Uniprot ID: P14314

Source protein: Glucosidase 2 subunit beta

Source gene: PRKCSH

Class: DEG_SPOP_SBC_1

Location: 491:495

E3 ligase: SPOP

DEGRON score: 0.6641

ASA_SCORE: 46.14

COIL: 0.049

CONS_SCORE: 0.5915

DSS_SCORE: 0.367

HELIX: 0.0026

FCONS_SCORE: 0.9395

RIG_SCORE: 0.7505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G486V	TCGA-55-8089	LUAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1944
p.S498N	TCGA-CM-4743	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.6944
p.M490I	TCGA-HC-8256	PRAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.3056
p.M490I	TCGA-SX-A7SP	KIRP	TCGA	VTSTT	DEG_SPOP_SBC_1	0.3056
p.R482C	TCGA-IB-7651	PAAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0833
p.T487P	DO51936	BLCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.6667
p.S505N	DO8103	COAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.R484H	DO222755	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.R484H	DO41361	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.R489C	DO233823	GACA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2778
p.R489C	DO46657	PAAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2778
p.M497I	DO49790	KIRP	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2778
p.M497I	DO49813	PRAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2778
p.E503D	DO228971	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1111
p.R489L	DO229022	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2778
p.G481C	DO229034	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.G481C	DO229542	UTCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.G493V	DO23690	LUAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons