DegronMD - P14314(PRKCSH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q362H	TCGA-3C-AALI	BRCA	TCGA	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.3056
p.G486V	TCGA-55-8089	LUAD	TCGA	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1944
p.P357R	TCGA-77-8009	LUSC	TCGA	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation altering degron motif	0.6401
p.P357S	TCGA-AJ-A3BG	UCEC	TCGA	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation altering degron motif	0.5641
p.P347L	TCGA-AX-A2IN	UCEC	TCGA	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.0833
p.P347L	ACH-000693	Esophageal Cancer	CCLE	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.0833
p.E353K	TCGA-CK-4951	COAD	TCGA	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.25
p.S498N	TCGA-CM-4743	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking phosphorylation signal	0.6944
p.M490I	TCGA-HC-8256	PRAD	TCGA	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.3056
p.M490I	TCGA-SX-A7SP	KIRP	TCGA	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.3056
p.R482C	TCGA-IB-7651	PAAD	TCGA	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0833
p.T487P	DO51936	BLCA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation blocking ubiquitination signal	0.6667
p.Q369H	DO219589	BRCA	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.1111
p.S505N	DO8103	COAD	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.E360K	DO10582	COAD	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation altering degron motif	0.7022
p.P352L	DO9732	COAD	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.2222
p.P352L	DO50449	ESAD	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.2222
p.P352L	DO41871	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.2222
p.R484H	DO222755	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.R484H	DO41361	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1389
p.R489C	DO233823	GACA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.R489C	DO46657	PAAD	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.M497I	DO49790	KIRP	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.M497I	DO49813	PRAD	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.E503D	DO228971	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.1111
p.R489L	DO229022	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.2778
p.S356I	DO229024	LICA	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation altering degron motif	0.7341
p.G481C	DO229034	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.G481C	DO229542	UTCA	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation rewiring degron network	0.0556
p.G493V	DO23690	LUAD	ICGC	VTSTT	DEG_SPOP_SBC_1	491:495	Mutation altering degron motif	0.7532
p.P364R	DO27200	LUSC	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.25
p.P351L	DO50291	SKCM	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.1944
p.P354L	DO42328	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.2778
p.P364L	DO42825	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.25
p.P364S	DO42633	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	356:361	Mutation rewiring degron network	0.25

Kaplan plot for PRKCSH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRKCSH

UniProt ID: P14314

Entrez ID: 5589

Protein name: Glucosidase 2 subunit beta (80K-H protein) (Glucosidase II subunit beta) (Protein kinase C substrate 60.1 kDa protein heavy chain) (PKCSH)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRKCSH in