DegronMD

Uniprot ID: P14314

Source protein: Glucosidase 2 subunit beta

Source gene: PRKCSH

Class: LIG_APCC_ABBA_1

Location: 356:361

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9951

ASA_SCORE: 81.45

COIL: 0.788

CONS_SCORE: 0.4143

DSS_SCORE: 0.8307

HELIX: 0.1893

FCONS_SCORE: 1.0426

RIG_SCORE: 0.6345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q362H	TCGA-3C-AALI	BRCA	TCGA	MPPYDE	LIG_APCC_ABBA_1	0.3056
p.P357R	TCGA-77-8009	LUSC	TCGA	MPPYDE	LIG_APCC_ABBA_1	0.6401
p.P357S	TCGA-AJ-A3BG	UCEC	TCGA	MPPYDE	LIG_APCC_ABBA_1	0.5641
p.P347L	TCGA-AX-A2IN	UCEC	TCGA	MPPYDE	LIG_APCC_ABBA_1	0.0833
p.P347L	ACH-000693	Esophageal Cancer	CCLE	MPPYDE	LIG_APCC_ABBA_1	0.0833
p.E353K	TCGA-CK-4951	COAD	TCGA	MPPYDE	LIG_APCC_ABBA_1	0.25
p.Q369H	DO219589	BRCA	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.1111
p.E360K	DO10582	COAD	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.7022
p.P352L	DO9732	COAD	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.2222
p.P352L	DO50449	ESAD	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.2222
p.P352L	DO41871	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.2222
p.S356I	DO229024	LICA	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.7341
p.P364R	DO27200	LUSC	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.25
p.P351L	DO50291	SKCM	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.1944
p.P354L	DO42328	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.2778
p.P364L	DO42825	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.25
p.P364S	DO42633	UCEC	ICGC	MPPYDE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14314	Glucosidase 2 subunit beta	LIG_APCC_ABBA_1	356:361	MPPYDE	APC,CDC20,FZR1	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons