DegronMD - Q7Z2W4(ZC3HAV1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V489L	TCGA-60-2710	LUSC	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1389
p.V489L	DO26938	LUSC	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1389
p.T393P	TCGA-98-8021	LUSC	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.75
p.T393P	DO27468	LUSC	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.75
p.K401R	TCGA-AB-2833	LAML	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation blocking ubiquitination signal	0.5278
p.K401R	TCGA-AB-2833	LAML	TCGA	DYR	CBL_MET	409:411	Mutation blocking ubiquitination signal	0.5556
p.K401R	DO21679	LAML	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation blocking ubiquitination signal	0.5278
p.K401R	DO21679	LAML	ICGC	DYR	CBL_MET	409:411	Mutation blocking ubiquitination signal	0.5556
p.A384T	TCGA-AN-A046	BRCA	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6028
p.A384T	DO1285	BRCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6028
p.A384T	SIDM00282	Colorectal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6028
p.A384T	SIDM00999	Bladder Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6028
p.S501Y	TCGA-AP-A0LM	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.3056
p.S501Y	DO43306	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.3056
p.G418E	TCGA-AP-A1DK	UCEC	TCGA	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.1389
p.G418E	DO42033	UCEC	ICGC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.1389
p.L493S	TCGA-CA-6717	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.25
p.L493S	DO8264	COAD	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.25
p.S492Y	TCGA-CA-6718	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation blocking phosphorylation signal	0.6667
p.S492Y	DO7801	COAD	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation blocking phosphorylation signal	0.6667
p.L381V	TCGA-CH-5745	PRAD	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.25
p.L381V	DO36270	PRAD	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.25
p.L488F	TCGA-CZ-5465	KIRC	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1111
p.L488F	DO17502	KIRC	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.1111
p.L391M	TCGA-DF-A2KN	UCEC	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.5999
p.L391M	DO223282	UCEC	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.5999
p.L388P	TCGA-ER-A42L	SKCM	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.7582
p.L388P	DO223910	SKCM	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.7582
p.L388F	TCGA-ER-A42L	SKCM	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6981
p.L388F	DO223910	SKCM	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6981
p.R503M	TCGA-FS-A1ZG	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.25
p.R503M	DO37523	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.25
p.Q420E	TCGA-GC-A4ZW	BLCA	TCGA	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.0833
p.Q420E	DO219024	BLCA	ICGC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.0833
p.S501F	TCGA-GN-A266	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.3056
p.S501F	DO37432	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation rewiring degron network	0.3056
p.L391V	TCGA-HN-A2NL	BRCA	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.5654
p.L391V	DO219637	BRCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.5654
p.N414S	DO224612	COCA	ICGC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.25
p.T380M	DO222864	COCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation blocking phosphorylation signal	0.6667
p.T497K	DO229029	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation altering degron motif	0.6195
p.L405F	DO50790	LICA	ICGC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.2222
p.L406I	DO50790	LICA	ICGC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.25
p.L388V	SIDM01292	Esophageal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6765
p.G415V	SIDM01016	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.2222
p.G415V	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.2222
p.G415V	ACH-000995	Leukemia	CCLE	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.2222
p.G415V	Jurkat	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.2222
p.R385C	SIDM01265	Plasma Cell Myeloma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.8301
p.R385C	SIDM00930	Osteosarcoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.8301
p.R385C	SIDM01664	Prostate Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.8301
p.A384S	SIDM00217	Colorectal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6477
p.A384S	ACH-000999	Colon/Colorectal Cancer	CCLE	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6477
p.A384S	SNU-1040	large intestine	COSMIC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation altering degron motif	0.6477
p.G402D	SIDM01140	Ovarian Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.0556
p.G402D	SIDM01140	Ovarian Carcinoma	GDSC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.1389
p.G402D	ACH-001374	Ovarian Cancer	CCLE	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.0556
p.G402D	ACH-001374	Ovarian Cancer	CCLE	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.1389
p.G402D	PA-1	ovary	COSMIC	ARSSLGSLQ	DEG_APCC_DBOX_1	384:392	Mutation rewiring degron network	0.0556
p.G402D	PA-1	ovary	COSMIC	DYR	CBL_MET	409:411	Mutation rewiring degron network	0.1389
p.L498I	NCI-H1435	lung	COSMIC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation altering degron motif	0.7174
p.L498R	HT	haematopoietic and lymphoid tissue	COSMIC	VTSTT	DEG_SPOP_SBC_1	496:500	Mutation altering degron motif	0.8428

Kaplan plot for ZC3HAV1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3HAV1

UniProt ID: Q7Z2W4

Entrez ID: 56829

Protein name: Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3HAV1 in