DegronMD

Uniprot ID: Q7Z2W4

Source protein: Zinc finger CCCH-type antiviral protein 1

Source gene: ZC3HAV1

Class: DEG_APCC_DBOX_1

Location: 384:392

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9724

ASA_SCORE: 78.2444

COIL: 0.7804

CONS_SCORE: 0.2387

DSS_SCORE: 0.5122

HELIX: 0.1463

FCONS_SCORE: 0.9079

RIG_SCORE: 0.6736

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R385C	SIDM01265	Plasma Cell Myeloma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.8301
p.R385C	SIDM00930	Osteosarcoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.8301
p.R385C	SIDM01664	Prostate Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.8301
p.L388P	TCGA-ER-A42L	SKCM	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.7582
p.L388P	DO223910	SKCM	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.7582
p.T393P	TCGA-98-8021	LUSC	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.75
p.T393P	DO27468	LUSC	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.75
p.L388F	TCGA-ER-A42L	SKCM	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6981
p.L388F	DO223910	SKCM	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6981
p.L388V	SIDM01292	Esophageal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6765
p.T380M	DO222864	COCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6667
p.A384S	SIDM00217	Colorectal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6477
p.A384S	ACH-000999	Colon/Colorectal Cancer	CCLE	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6477
p.A384S	SNU-1040	large_intestine	COSMIC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6477
p.A384T	TCGA-AN-A046	BRCA	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.A384T	DO1285	BRCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.A384T	SIDM00282	Colorectal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.A384T	SIDM00999	Bladder Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.L391M	TCGA-DF-A2KN	UCEC	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5999
p.L391M	DO223282	UCEC	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5999
p.L391V	TCGA-HN-A2NL	BRCA	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5654
p.L391V	DO219637	BRCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5654
p.K401R	TCGA-AB-2833	LAML	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5278
p.K401R	DO21679	LAML	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5278
p.L381V	TCGA-CH-5745	PRAD	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.25

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Drug responses associated with ZC3HAV1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ARSSLGSLQ

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_APCC_DBOX_1	384:392	ARSSLGSLQ	APC,CDC20,FZR1	0.9724	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSSLGSLQ

Degron related mutations and impact score

Drug responses associated with ZC3HAV1 mutations

All proteins holding degron of ARSSLGSLQ