DegronMD

Uniprot ID: Q7Z2W4

Source protein: Zinc finger CCCH-type antiviral protein 1

Source gene: ZC3HAV1

Class: DEG_APCC_DBOX_1

Location: 384:392

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9724

ASA_SCORE: 78.2444

COIL: 0.7804

CONS_SCORE: 0.2387

DSS_SCORE: 0.5122

HELIX: 0.1463

FCONS_SCORE: 0.9079

RIG_SCORE: 0.6736

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T393P	TCGA-98-8021	LUSC	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.75
p.T393P	DO27468	LUSC	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.75
p.K401R	TCGA-AB-2833	LAML	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5278
p.K401R	DO21679	LAML	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5278
p.A384T	TCGA-AN-A046	BRCA	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.A384T	DO1285	BRCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.A384T	SIDM00282	Colorectal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.A384T	SIDM00999	Bladder Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6028
p.L381V	TCGA-CH-5745	PRAD	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.25
p.L381V	DO36270	PRAD	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.25
p.L391M	TCGA-DF-A2KN	UCEC	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5999
p.L391M	DO223282	UCEC	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5999
p.L388P	TCGA-ER-A42L	SKCM	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.7582
p.L388P	DO223910	SKCM	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.7582
p.L388F	TCGA-ER-A42L	SKCM	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6981
p.L388F	DO223910	SKCM	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6981
p.L391V	TCGA-HN-A2NL	BRCA	TCGA	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5654
p.L391V	DO219637	BRCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.5654
p.T380M	DO222864	COCA	ICGC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6667
p.L388V	SIDM01292	Esophageal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6765
p.R385C	SIDM01265	Plasma Cell Myeloma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.8301
p.R385C	SIDM00930	Osteosarcoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.8301
p.R385C	SIDM01664	Prostate Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.8301
p.A384S	SIDM00217	Colorectal Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6477
p.A384S	ACH-000999	Colon/Colorectal Cancer	CCLE	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6477
p.A384S	SNU-1040	large_intestine	COSMIC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.6477
p.G402D	SIDM01140	Ovarian Carcinoma	GDSC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.0556
p.G402D	ACH-001374	Ovarian Cancer	CCLE	ARSSLGSLQ	DEG_APCC_DBOX_1	0.0556
p.G402D	PA-1	ovary	COSMIC	ARSSLGSLQ	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSSLGSLQ

Degron related mutations and impact score

Drug responses associated with ZC3HAV1 mutations

All proteins holding degron of ARSSLGSLQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_APCC_DBOX_1	384:392	ARSSLGSLQ	APC,CDC20,FZR1	0.9724	More...