DegronMD

Uniprot ID: Q7Z2W4

Source protein: Zinc finger CCCH-type antiviral protein 1

Source gene: ZC3HAV1

Class: DEG_SPOP_SBC_1

Location: 496:500

E3 ligase: SPOP

DEGRON score: 0.9962

ASA_SCORE: 78.54

COIL: 0.8346

CONS_SCORE: 0.3781

DSS_SCORE: 0.4772

HELIX: 0.1112

FCONS_SCORE: 1.2686

RIG_SCORE: 0.6896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V489L	TCGA-60-2710	LUSC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1389
p.V489L	DO26938	LUSC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.S501Y	TCGA-AP-A0LM	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.3056
p.S501Y	DO43306	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L493S	TCGA-CA-6717	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.25
p.L493S	DO8264	COAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.25
p.S492Y	TCGA-CA-6718	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.6667
p.S492Y	DO7801	COAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.6667
p.L488F	TCGA-CZ-5465	KIRC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1111
p.L488F	DO17502	KIRC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1111
p.R503M	TCGA-FS-A1ZG	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.25
p.R503M	DO37523	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.25
p.S501F	TCGA-GN-A266	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.3056
p.S501F	DO37432	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.T497K	DO229029	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.6195
p.L498I	NCI-H1435	lung	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.7174
p.L498R	HT	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons