DegronMD

Uniprot ID: Q96RI1

Source protein: Bile acid receptor

Source gene: NR1H4

Class: DEG_SPOP_SBC_1

Location: 246:250

E3 ligase: SPOP

DEGRON score: 0.6186

ASA_SCORE: 55.88

COIL: 0.5148

CONS_SCORE: 0.5041

DSS_SCORE: 0.5493

HELIX: 0.3558

FCONS_SCORE: 1.1253

RIG_SCORE: 0.7149

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T257S	TCGA-B0-5097	KIRC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1389
p.G240D	TCGA-D3-A2JC	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1667
p.S252L	TCGA-EE-A2GB	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.2778
p.D242Y	TCGA-KQ-A41N	BLCA	TCGA	VTSTT	DEG_SPOP_SBC_1	0.2222
p.E255D	TCGA-QF-A5YS	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1944
p.R241C	TCGA-W3-AA1V	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1944
p.P251T	DO225349	BRCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.T247S	DO19370	KIRC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.6005
p.K241N	DO229036	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1944
p.S242L	DO222683	MELA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2222
p.S242L	DO37417	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2222
p.E245D	DO52426	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.T241M	RF-48	stomach	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.1944
p.K256Q	SW948	large_intestine	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.2778

Drug responses associated with NR1H4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q98H (No)	GDSC	T0901317	263.5381
SIDM00327	UNCLASSIFIED\|Hodgkin_lymphoma	p.Y208C (No)	GDSC	T0901317	33.4423
SIDM01031	ESCA\|oesophagus	p.R331H (No)	GDSC	T0901317	84.2155
SIDM00929	UNCLASSIFIED\|chondrosarcoma	p.R90H (No)	GDSC	T0901317	162.8099
SIDM01036	MM\|haematopoietic_neoplasm_other	p.G307* (No)	GDSC	T0901317	12.8735
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.V232fs*1 (No)	GDSC	T0901317	263.5381
SIDM01191	UNCLASSIFIED\|osteosarcoma	p.I388S (No)	GDSC	T0901317	80.386
SIDM01058	DLBC\|B_cell_lymphoma	p.D400G (No)	GDSC	T0901317	33.5246
SIDM00718	LUAD\|lung_NSCLC_adenocarcinoma	p.P34H (No)	GDSC	T0901317	150.8011
SIDM00220	OV\|ovary	p.R133G (No)	GDSC	T0901317	52.2996
SIDM00518	MESO\|mesothelioma	p.A324V (No)	GDSC	T0901317	101.7523
SIDM00619	THCA\|thyroid	p.S68C (No)	GDSC	T0901317	81.0817
SIDM01092	STAD\|stomach	p.T288M (No)	GDSC	T0901317	134.2365
SIDM01126	SCLC\|lung_small_cell_carcinoma	p.L311S (No)	GDSC	T0901317	19.7236
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.V471A (No)	GDSC	T0901317	125.2249
SIDM00217	COREAD\|large_intestine	p.R176* (No)	GDSC	T0901317	103.1363
SIDM00217	COREAD\|large_intestine	p.R353* (No)	GDSC	T0901317	103.1363
SIDM00217	COREAD\|large_intestine	p.Y397C (No)	GDSC	T0901317	103.1363
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.M452I (No)	GDSC	T0901317	47.3699
SIDM00948	UNCLASSIFIED\|Burkitt_lymphoma	p.S82P (No)	GDSC	T0901317	33.6806
SIDM00216	COREAD\|large_intestine	p.G343E (No)	GDSC	T0901317	40.369
SIDM00053	PAAD\|pancreas	p.K111N (No)	GDSC	T0901317	106.0988
SIDM00282	COREAD\|large_intestine	p.A134V (No)	GDSC	T0901317	78.7744
SIDM01134	SCLC\|lung_small_cell_carcinoma	p.S82C (No)	GDSC	T0901317	57.819
SIDM00406	DLBC\|B_cell_lymphoma	p.E314A (No)	GDSC	T0901317	27.7071
SIDM00660	COREAD\|large_intestine	p.S22Y (No)	GDSC	T0901317	133.1875
SIDM00879	BRCA\|breast	p.M30V (No)	GDSC	T0901317	36.6635
SIDM00832	COREAD\|large_intestine	p.K303Q (No)	GDSC	T0901317	234.554
SIDM00737	UNCLASSIFIED\|lung_NSCLC_not_specified	p.R353Q (No)	GDSC	T0901317	125.1769
SIDM00304	OV\|ovary	p.G99E (No)	GDSC	T0901317	106.864
SIDM00789	COREAD\|large_intestine	p.C20* (No)	GDSC	T0901317	58.1262
SIDM00789	COREAD\|large_intestine	p.K213N (No)	GDSC	T0901317	58.1262
SIDM00534	COREAD\|large_intestine	p.R177K (No)	GDSC	T0901317	40.2064
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.Q249* (Yes)	GDSC	T0901317	195.8725
SIDM01116	UNCLASSIFIED\|lung_NSCLC_large_cell	p.A280E (No)	GDSC	T0901317	82.8528
SIDM00119	LUAD\|lung_NSCLC_adenocarcinoma	p.T386R (No)	GDSC	T0901317	734.8504
SIDM00700	UNCLASSIFIED\|lung_NSCLC_not_specified	p.Q379E (No)	GDSC	T0901317	184.7577
SIDM00581	GBM\|glioma	p.R90H (No)	GDSC	T0901317	165.0098
SIDM00365	SCLC\|lung_small_cell_carcinoma	p.P22L (No)	GDSC	T0901317	181.6829
SIDM00390	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.N354H (No)	GDSC	T0901317	27.8783
SIDM00238	OV\|ovary	p.A448T (No)	GDSC	T0901317	79.6875
SIDM00193	COREAD\|large_intestine	p.E300* (No)	GDSC	T0901317	213.5921
SIDM00193	COREAD\|large_intestine	p.R353* (No)	GDSC	T0901317	213.5921
SIDM00193	COREAD\|large_intestine	p.S453P (No)	GDSC	T0901317	213.5921
SIDM00118	COREAD\|large_intestine	p.R176Q (No)	GDSC	T0901317	128.3327

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTT

Degron related mutations and impact score

Drug responses associated with NR1H4 mutations

All proteins holding degron of VTSTT