DegronMD

Uniprot ID: P13611

Source protein: Versican core protein

Source gene: VCAN

Class: DEG_SPOP_SBC_1

Location: 2327:2331

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 81.04

COIL: 0.8186

CONS_SCORE: 0.4238

DSS_SCORE: 0.3737

HELIX: 0.0236

FCONS_SCORE: 1.0011

RIG_SCORE: 0.7819

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I2335S	TCGA-A5-A0G2	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.2222
p.I2335S	DO41235	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.2222
p.T2318A	TCGA-AA-A010	COAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0833
p.S2329I	TCGA-AX-A06F	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.7341
p.S2329I	DO41752	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7341
p.L2336V	TCGA-F5-6814	READ	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1944
p.L2336V	DO36556	READ	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1944
p.G2340A	TCGA-FD-A6TH	BLCA	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0833
p.G2340A	DO49763	BLCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0833
p.G2340E	TCGA-HZ-7926	PAAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0833
p.G2340E	DO32759	PAAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0833
p.D2319H	DO222379	MELA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1111
p.C2338R	AN3-CA	endometrium	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.F2321L	PC-3	prostate	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.1667
p.S2332F	IPC-298	skin	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.R2327C	SNU-81	large_intestine	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons