DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 960:964

E3 ligase: SPOP

DEGRON score: 0.9606

ASA_SCORE: 94.1

COIL: 0.9616

CONS_SCORE: 0.2159

DSS_SCORE: 0.4329

HELIX: 0.0156

FCONS_SCORE: 0.9365

RIG_SCORE: 0.7646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E950K	TCGA-AG-3892	READ	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	TCGA-AP-A056	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	TCGA-DF-A2KU	UCEC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	TCGA-EI-6917	READ	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	DO232761	PBCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	DO36394	READ	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	DO36881	READ	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	DO223286	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	DO43971	UCEC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	SIDM01611	Endometrial Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	SIDM01588	Endometrial Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	ACH-000993	Endometrial/Uterine Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E950K	ACH-000996	Endometrial/Uterine Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	0.0556
p.Q959E	DO231984	LICA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.S962C	SIDM00679	Cervical Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	0.8652
p.S962C	ACH-001525	Cervical Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	0.8652
p.S962C	HT-3	cervix	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.8652
p.T957S	SIDM00503	Gastric Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	0.25
p.T957S	FU97	stomach	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.25
p.T951A	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.0833
p.A973T	LS-411N	large_intestine	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.0833
p.T953A	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.S964L	NCI-H810	lung	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.7667
p.T963A	EN	endometrium	COSMIC	VTSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons