DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 429:433

E3 ligase: SPOP

DEGRON score: 0.6306

ASA_SCORE: 88.7

COIL: 0.8572

CONS_SCORE: 0.4534

DSS_SCORE: 0.5459

HELIX: 0.016

FCONS_SCORE: 1

RIG_SCORE: 0.7348

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V439I	TCGA-06-6388	GBM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1667
p.V439I	TCGA-27-1834	GBM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1667
p.V439I	DO233154	GACA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1667
p.V439I	DO13300	GBM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1667
p.V439I	DO14109	GBM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1667
p.V431A	TCGA-44-7670	LUAD	TCGA	VTSTT	DEG_SPOP_SBC_1	0.6936
p.V431A	DO23555	LUAD	ICGC	VTSTT	DEG_SPOP_SBC_1	0.6936
p.S422I	TCGA-56-A62T	LUSC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1389
p.S422I	DO219144	LUSC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.S440C	TCGA-98-8021	LUSC	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1389
p.S440C	DO27468	LUSC	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1389
p.P443S	TCGA-BF-A3DL	SKCM	TCGA	VTSTT	DEG_SPOP_SBC_1	0.0556
p.P443S	DO51238	SKCM	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0556
p.E423K	TCGA-G2-A2EF	BLCA	TCGA	VTSTT	DEG_SPOP_SBC_1	0.1667
p.E423K	DO726	BLCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.1667
p.L434P	DO229010	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO229013	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO229016	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO229003	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO229005	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO50980	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO51040	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO51026	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434P	DO229257	THCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO229010	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO229013	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO229016	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO229003	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO229005	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO50980	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO51040	LAML	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.L434I	DO229253	THCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.S429N	DO229010	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7069
p.S429N	DO229013	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7069
p.S429N	DO229016	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7069
p.S429N	DO229003	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7069
p.S429N	DO229005	COCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7069
p.S429N	DO229140	THCA	ICGC	VTSTT	DEG_SPOP_SBC_1	0.7069
p.I442N	DO46372	OV	ICGC	VTSTT	DEG_SPOP_SBC_1	0.0833
p.M428V	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	VTSTT	DEG_SPOP_SBC_1	0.3056
p.P437T	ACH-000893	Lung Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	0.2222
p.E423D	ACH-000989	Colon/Colorectal Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	0.1667
p.P433L	ACH-001550	Skin Cancer	CCLE	VTSTT	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	2327:2331	VTSTT	SPOP	0.9991	More...
P14314	Glucosidase 2 subunit beta	DEG_SPOP_SBC_1	491:495	VTSTT	SPOP	0.6641	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	429:433	VTSTT	SPOP	0.6306	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1181:1185	VTSTT	SPOP	0.8202	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5539:5543	VTSTT	SPOP	0.9748	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	DEG_SPOP_SBC_1	496:500	VTSTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	960:964	VTSTT	SPOP	0.9606	More...
Q96RI1	Bile acid receptor	DEG_SPOP_SBC_1	246:250	VTSTT	SPOP	0.6186	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VTSTT

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of VTSTT