DegronMD

Uniprot ID: Q5CZC0

Source protein: Fibrous sheath-interacting protein 2

Source gene: FSIP2

Class: DEG_SPOP_SBC_1

Location: 5734:5738

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 74.14

COIL: 0.8444

CONS_SCORE: 0.5094

DSS_SCORE: 0.5559

HELIX: 0.0956

FCONS_SCORE: 0.9877

RIG_SCORE: 0.6348

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K5724N	TCGA-44-2662	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.D5748N	TCGA-BF-AAP4	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	0.0556
p.D5748N	DO229446	SKCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.D5748N	DO219468	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	0.0556
p.E5744K	TCGA-BT-A20J	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	0.1667
p.E5744K	DO457	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.R5739G	TCGA-D6-A4ZB	HNSC	TCGA	VSSST	DEG_SPOP_SBC_1	0.3056
p.R5739G	DO44446	HNSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.R5739Q	TCGA-DK-A6AW	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	0.3056
p.R5739Q	TCGA-EE-A3JD	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	0.3056
p.R5739Q	DO48566	BLCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.R5739Q	DO50299	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	0.3056
p.L5727I	TCGA-DK-AA6R	BLCA	TCGA	VSSST	DEG_SPOP_SBC_1	0.1389
p.L5727I	TCGA-EY-A215	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1389
p.L5727I	TCGA-GR-A4D9	DLBC	TCGA	VSSST	DEG_SPOP_SBC_1	0.1389
p.T5731A	TCGA-EO-A3AV	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	0.25
p.T5731A	DO52412	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	0.25
p.N5743I	TCGA-HU-8249	STAD	TCGA	VSSST	DEG_SPOP_SBC_1	0.1944
p.S5737L	DO219080	HNSC	ICGC	VSSST	DEG_SPOP_SBC_1	0.7667
p.E5744D	DO229036	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	0.1667
p.E5735K	DO229453	SKCA	ICGC	VSSST	DEG_SPOP_SBC_1	0.7022
p.S5728P	SIDM00262	Ewing's Sarcoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.1667
p.S5728P	ACH-002107	Bone Cancer	CCLE	VSSST	DEG_SPOP_SBC_1	0.1667
p.S5728P	ES6	bone	COSMIC	VSSST	DEG_SPOP_SBC_1	0.1667
p.T5738A	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	0.7139
p.T5738A	ACH-002256	Leukemia	CCLE	VSSST	DEG_SPOP_SBC_1	0.7139
p.T5738A	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	0.7139
p.K5733I	SIDM00539	Esophageal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.75
p.K5733I	SIDM00954	Breast Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.75
p.K5733I	SIDM01140	Ovarian Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60237	Protein phosphatase 1 regulatory subunit 12B	DEG_SPOP_SBC_1	574:578	VSSST	SPOP	0.9726	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2573:2577	VSSST	SPOP	0.768	More...
O75496	Geminin	DEG_SPOP_SBC_1	199:203	VSSST	SPOP	0.9991	More...
O95935	T-box transcription factor TBX18	DEG_SPOP_SBC_1	460:464	VSSST	SPOP	0.9891	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1797:1801	VSSST	SPOP	0.9347	More...
Q12951	Forkhead box protein I1	DEG_SPOP_SBC_1	222:226	VSSST	SPOP	0.9895	More...
Q13433	Zinc transporter ZIP6	DEG_SPOP_SBC_1	218:222	VSSST	SPOP	0.9963	More...
Q13516	Oligodendrocyte transcription factor 2	DEG_SPOP_SBC_1	39:43	VSSST	SPOP	0.9992	More...
Q2LD37	Transmembrane protein KIAA1109	DEG_SPOP_SBC_1	4029:4033	VSSST	SPOP	0.5866	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	5734:5738	VSSST	SPOP	0.9977	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2933:2937	VSSST	SPOP	0.996	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	1005:1009	VSSST	SPOP	0.9988	More...
Q8NEZ2	Vacuolar protein sorting-associated protein 37A	DEG_SPOP_SBC_1	179:183	VSSST	SPOP	0.9741	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	835:839	VSSST	SPOP	0.9941	More...
Q96IZ0	PRKC apoptosis WT1 regulator protein	DEG_SPOP_SBC_1	263:267	VSSST	SPOP	0.7604	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	155:159	VSSST	SPOP	0.9548	More...
Q9UJT9	F-box/LRR-repeat protein 7	DEG_SPOP_SBC_1	23:27	VSSST	SPOP	0.9977	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	659:663	VSSST	SPOP	0.9709	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	365:369	VSSST	SPOP	0.9057	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSST

Degron related mutations and impact score

Drug responses associated with FSIP2 mutations

All proteins holding degron of VSSST