DegronMD - Q13433(SLC39A6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D101Y	TCGA-44-6778	LUAD	TCGA	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.1667
p.D101Y	TCGA-44-6778	LUAD	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.D101Y	DO25603	LUAD	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.1667
p.D101Y	DO25603	LUAD	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.D217V	TCGA-64-1676	LUAD	TCGA	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.D217V	DO23629	LUAD	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.H105Q	TCGA-A5-A0G2	UCEC	TCGA	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.0556
p.H105Q	TCGA-A5-A0G2	UCEC	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0556
p.H105Q	DO41235	UCEC	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.0556
p.H105Q	DO41235	UCEC	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0556
p.V226A	TCGA-AJ-A3EL	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.V226A	DO41542	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.D95G	TCGA-AP-A0LM	UCEC	TCGA	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.7198
p.D95G	TCGA-AP-A0LM	UCEC	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7198
p.D95G	DO43306	UCEC	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.7198
p.D95G	DO43306	UCEC	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7198
p.H91Y	TCGA-EE-A181	SKCM	TCGA	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.6118
p.H91Y	TCGA-EE-A181	SKCM	TCGA	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6118
p.H91Y	DO37444	SKCM	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.6118
p.H91Y	DO37444	SKCM	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6118
p.P210S	TCGA-EE-A29G	SKCM	TCGA	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.P210S	DO47303	SKCM	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.V232M	DO234377	ESAD	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0556
p.S219R	DO228952	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6316
p.H93N	DO228971	LICA	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.7423
p.H93N	DO228971	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7423
p.H93N	DO229018	LICA	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.7423
p.H93N	DO229018	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.7423
p.Q80K	DO229028	LICA	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.0556
p.Q80K	DO229028	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.0833
p.P210T	DO229027	LICA	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.H99N	DO229026	LICA	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.2222
p.H99N	DO229026	LICA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.2222
p.P223L	DO230929	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.P223L	DO224572	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.D97E	DO46850	RECA	ICGC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.2778
p.D97E	DO46850	RECA	ICGC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.2778
p.H93Y	SIDM01293	Colorectal Carcinoma	GDSC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation altering degron motif	0.6118
p.H93Y	SIDM01293	Colorectal Carcinoma	GDSC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation altering degron motif	0.6118
p.G83D	SIDM00217	Colorectal Carcinoma	GDSC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.1389
p.G83D	SIDM00217	Colorectal Carcinoma	GDSC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.G83D	ACH-000999	Colon/Colorectal Cancer	CCLE	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.1389
p.G83D	ACH-000999	Colon/Colorectal Cancer	CCLE	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.G83D	SNU-1040	large intestine	COSMIC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.1389
p.G83D	SNU-1040	large intestine	COSMIC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1667
p.K216E	ACH-001143	Lymphoma	CCLE	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.D217A	ACH-001540	Liposarcoma	CCLE	VSSST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.S84R	IGROV-1	ovary	COSMIC	IHIHHD	LIG_APCC_ABBA_1	90:95	Mutation rewiring degron network	0.1667
p.S84R	IGROV-1	ovary	COSMIC	RIHIHHD	LIG_APCC_ABBAyCdc20_2	89:95	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC39A6

UniProt ID: Q13433

Entrez ID: 25800

Protein name: Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC39A6 in